Jack J. Kinsora

Pfizer (United States) — United States

Neuroscience · Life Sciences

12h-index605citations17works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(8), Receptor Mechanisms and Signaling(4), Cholinesterase and Neurodegenerative Diseases(3), Synthesis and pharmacology of benzodiazepine derivatives(3), Protein Kinase Regulation and GTPase Signaling(2)

Publications17 total

Oxadiazolone bioisosteres of pregabalin and gabapentin
Bioorganic & Medicinal Chemistry Letters·2008· 14 cited
ChemInform Abstract: Synthesis and SAR of 2‐Aryl Pyrido[2,3‐d]pyrimidines as Potent mGlu5 Receptor Antagonists.
ChemInform·2008
Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 29 citedOpen Access
Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 29 citedOpen Access
Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 23 citedOpen Access
Heteroaromatic Side‐Chain Analogues of Pregabalin.
ChemInform·2006
Carboxylate bioisosteres of pregabalin
Bioorganic & Medicinal Chemistry Letters·2006· 16 cited
Activity profile of pregabalin in rodent models of epilepsy and ataxia
Epilepsy Research·2005· 91 cited
Heteroaromatic side-chain analogs of pregabalin
Bioorganic & Medicinal Chemistry Letters·2005· 23 citedOpen Access
Carboxylate bioisosteres of gabapentin
Bioorganic & Medicinal Chemistry Letters·2005· 22 citedOpen Access
Novel Cyclopropyl β-Amino Acid Analogues of Pregabalin and Gabapentin That Target the α<sub>2</sub>-δ Protein
Journal of Medicinal Chemistry·2005· 45 cited
Structure−Activity Relationships of Pregabalin and Analogues That Target the α<sub>2</sub>-δ Protein
Journal of Medicinal Chemistry·2005· 208 cited
P.3.040 Contribution of high-affinity binding at calcium channel α2-δ proteins to the pharmacology of pregabalin
European Neuropsychopharmacology·2004
Milameline (CI-979/RU35926): A Muscarinic Receptor Agonist with Cognition-Activating Properties: Biochemical and In Vivo Characterization
Journal of Pharmacology and Experimental Therapeutics·1999· 45 cited
The novel use of vascular access ports for intravenous self-administration and blood withdrawal studies in squirrel monkeys
Journal of Neuroscience Methods·1997· 3 cited
Continuous ICV infusion of scopolamine impairs sustained attention of rhesus monkeys
Neurobiology of Aging·1993· 57 cited
Cholinergic agents: Deficits in rat hippocampal choline acetyltransferase activity and spatial working memory induced by intracerebroventricular administration of stoichiometrically prepared 1‐ethyl‐1‐(2‐hydroxyethyl) aziridinium ion (AF64A)
Drug Development Research·1991

Frequent Co-authors

Mark G. Vartanian(9), David J. Wustrow(8), Charles P. Taylor(6), Roy D. Schwarz(6), Jacob B. Schwarz(5), Andrew Thorpe(5), Susan M. Lotarski(5), Ayman El‐Kattan(4), Sean D. Donevan(4), John A. Wendt(4), Christopher S. Knauer(4), Corinne E. Augelli‐Szafran(4), Thomas R. Belliotti(3), Thomas Capiris(3), Mark J. Field(3), Melvin R. Dickerson(3), Ti‐Zhi Su(3), Susan E. Bove(3), Rachel M. Brooker(3), Kenneth S. Kilgore(3)