Lace M. Riggs

Neuroscience · Life Sciences

14h-index2.5kcitations31works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(13), Tryptophan and brain disorders(12), Treatment of Major Depression(10), Stress Responses and Cortisol(9), Neuroendocrine regulation and behavior(6)

Publications31 total

Bioactive ketamine metabolite exerts in vivo neuroplastogenic effects to improve hippocampal function in a treatment-resistant depression model
Cell Reports·2025Open Access
cAMP-dependent protein kinase signaling is required for (<i>2R,6R</i>)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission
Journal of Neurophysiology·2023· 12 citedOpen Access
CCDC 2265272: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
(2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity
Neuropharmacology·2022· 13 citedOpen Access
Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder
Molecular Psychiatry·2022· 8 citedOpen Access
P390. Synaptic Mechanisms by Which (2R,6R)-Hydroxynorketamine Promotes Hippocampal-Dependent Plasticity and Behavior
Biological Psychiatry·2022
Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2<i>,</i>6)- and (5<i>R</i>)-Methyl-(2<i>R,</i>6<i>R</i>)-hydroxynorketamines
ACS Chemical Neuroscience·2022· 23 citedOpen Access
Mechanisms of ketamine and its metabolites as antidepressants
Biochemical Pharmacology·2021· 150 citedOpen Access
(R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency
Translational Psychiatry·2021· 18 citedOpen Access
41. A RARE VARIANT IN D-AMINO ACID OXIDASE IMPLICATES NMDA RECEPTOR SIGNALING AND CEREBELLAR GENE NETWORKS IN RISK FOR BIPOLAR DISORDER
European Neuropsychopharmacology·2021· 2 cited
Environmental enrichment mitigates the long-lasting sequelae of perinatal fentanyl exposure
2021Open Access
A rare variant in D-amino acid oxidase implicates NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder
2021· 2 citedOpen Access
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications
Pharmacological Reviews·2021· 92 citedOpen Access
Ketamine and the Future of Rapid-Acting Antidepressants
Annual Review of Clinical Psychology·2021· 78 citedOpen Access
P199 - HILIC UPLC-MS/MS methods for the assessment of hydroxynorketamines pharmacokinetics in mouse plasma and brain
Drug Metabolism and Pharmacokinetics·2020· 1 cited
(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism
Neuropsychopharmacology·2019· 63 citedOpen Access
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Pharmacological Reviews·2018· 1.2k citedOpen Access
Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence
Neuron·2017· 109 citedOpen Access
Vicarious Social Defeat Stress Induces Depression-Related Outcomes in Female Mice
Biological Psychiatry·2017· 198 citedOpen Access
Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility
Journal of Neuroscience·2017· 51 citedOpen Access
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Frequent Co-authors

Todd D. Gould(16), Sergio D. Iñiguez(10), Edna F. R. Pereira(7), Steven J. Nieto(6), Panos Zanos(5), Patrick J. Morris(5), Jaclyn N. Highland(5), Craig J. Thomas(5), Scott M. Thompson(5), Ruin Moaddel(4), Mary Kay Lobo(4), Genesis Dayrit(3), Norma N. Zamora(3), Jason Bondoc Alipio(3), Kylie M. Konrath(3), Amy Q. Wang(3), Arturo R. Zavala(3), Naushaba Hasin(3), Tatyana Shekhtman(3), J. R. Ashworth(3)