Patrick J. Morris

National Institutes of Health — United States

Medicine · Health Sciences

33h-index7.0kcitations132works7.32yr avg
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Research Topics

Treatment of Major Depression(20), Crystallization and Solubility Studies(17), X-ray Diffraction in Crystallography(17), Tryptophan and brain disorders(16), Neuroscience and Neuropharmacology Research(13)

Publications132 total

Data‐Independent Acquisition Enhancement of a Competitive Activity‐Based Protein Profiling Platform for Kinase Inhibitor Screening
Journal of Mass Spectrometry·2026Open Access
An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors
ACS Pharmacology & Translational Science·2025Open Access
Discovery and Optimization of LATS1 and LATS2 Kinase Inhibitors for Use in Regenerative Medicine
Journal of Medicinal Chemistry·2025Open Access
A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2<i>R</i>,6<i>R</i>)‐Hydroxynorketamine in Healthy Volunteers
Clinical Pharmacology & Therapeutics·2024· 29 citedOpen Access
Comparative Assessment and High-Throughput Drug-Combination Profiling of TEAD-Palmitoylation Inhibitors in Hippo Pathway Deficient Mesothelioma
Pharmaceuticals·2023· 11 citedOpen Access
CCDC 2265272: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search
Molecular Psychiatry·2022· 41 citedOpen Access
The show must go on. Reply to “Distinct functions of S-ketamine and R-ketamine in mediating biobehavioral processes of drug dependency: comments on Bonaventura et al” by Insop Shim
Molecular Psychiatry·2022· 1 cited
Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration
Translational Psychiatry·2022· 31 citedOpen Access
Time will tell. Reply to “Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al.” by Chen et al.
Molecular Psychiatry·2022· 6 citedOpen Access
Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2<i>,</i>6)- and (5<i>R</i>)-Methyl-(2<i>R,</i>6<i>R</i>)-hydroxynorketamines
ACS Chemical Neuroscience·2022· 23 citedOpen Access
A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801
Neurotoxicology and Teratology·2021· 25 citedOpen Access
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
Molecular Psychiatry·2021· 246 citedOpen Access
Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo
Microorganisms·2021· 18 citedOpen Access
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications
Pharmacological Reviews·2021· 92 citedOpen Access
Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs Against Ebola Virus In Vivo
Preprints.org·2021· 1 citedOpen Access
18F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography
European Journal of Medicinal Chemistry·2020· 10 citedOpen Access
Zanos et al. reply
UNC Libraries·2020Open Access
Abstract B06: Development of selective LATS1/LATS2 inhibitors for the pharmacologic modulation of the Hippo signaling pathway
Molecular Cancer Research·2020
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Carolina Digital Repository (University of North Carolina at Chapel Hill)·2020Open Access
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Frequent Co-authors

Craig J. Thomas(24), Ruin Moaddel(17), Todd D. Gould(16), Panos Zanos(15), Carlos A. Zarate(15), Polymnia Georgiou(6), Jaclyn N. Highland(6), Jacqueline Lovett(6), Peixiong Yuan(5), Edson X. Albuquerque(5), Scott M. Thompson(5), Lace M. Riggs(3), Edna F. R. Pereira(3), Rajarshi Guha(3), Carleen Klumpp‐Thomas(3), Crystal McKnight(3), Jordi Bonaventura(3), Sherry Lam(3), Juan L. Gomez(3), Marta Sánchez‐Soto(3)