Michael R. Botchan

University of California, Berkeley — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

73h-index21.7kcitations161works0.02yr avg
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Research Topics

DNA Repair Mechanisms(57), Virus-based gene therapy research(48), Genomics and Chromatin Dynamics(38), DNA and Nucleic Acid Chemistry(22), CRISPR and Genetic Engineering(20)

Publications161 total

Editor's evaluation: Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila
2022Open Access
Editor's evaluation: MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells
2022Open Access
Decision letter: MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells
2022Open Access
Editor's evaluation: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
2021Open Access
Author response: Molecular determinants of phase separation for Drosophila DNA replication licensing factors
2021Open Access
Molecular determinants of phase separation for <i>Drosophila</i> DNA replication licensing factors
2021Open Access
Structural Mechanisms for Replicating DNA in Eukaryotes
Annual Review of Biochemistry·2021· 62 cited
Decision letter: DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7
2021Open Access
A new class of disordered elements controls DNA replication through initiator self-assembly
eLife·2019· 124 citedOpen Access
Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome
Cell Reports·2019· 106 citedOpen Access
Author response: A new class of disordered elements controls DNA replication through initiator self-assembly
2019Open Access
A new class of disordered elements controls DNA replication through initiator self-assembly
2019· 9 citedOpen Access
Decision letter: A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding
2019Open Access
Conformational control and DNA-binding mechanism of the metazoan origin recognition complex
Proceedings of the National Academy of Sciences·2018· 40 citedOpen Access
Mechanisms for initiating cellular DNA replication
Science·2017· 236 cited
Mechanisms and regulation of DNA replication initiation in eukaryotes
Critical Reviews in Biochemistry and Molecular Biology·2017· 184 citedOpen Access
Coordinating DNA replication with licensing concept
2016
Crystal structure of the eukaryotic origin recognition complex
Nature·2015· 136 citedOpen Access
Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement
Proceedings of the National Academy of Sciences·2015· 96 citedOpen Access
Chromatin reader L(3)mbt requires the Myb–MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment
Proceedings of the National Academy of Sciences·2014· 22 citedOpen Access
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Frequent Co-authors

James M. Berger(7), Monika Lusky(4), Ivar Ilves(4), Ian Mohr(4), Eileen L. Beall(4), Peter W. Lewis(3), Tatjana Petojevic(3), William C. Topp(3), Joe Sambrook(3), Daniel T.S. Pak(3), Igor Chesnokov(3), Liu Yang(3), James J. Pesavento(2), Michelle Pflumm(2), Da Wei Huang(2), Rebecca Kellum(2), Robin Clark(2), Rong Li(2), Alessandro Costa(2), Jonathan D. Knight(2)