Sridhar Sreeramulu

Goethe University Frankfurt — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index1.9kcitations149works5.52yr avg
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Research Topics

RNA and protein synthesis mechanisms(20), Computational Drug Discovery Methods(19), Protein Structure and Dynamics(16), Enzyme Structure and Function(14), SARS-CoV-2 and COVID-19 Research(13)

Publications148 total

Rapid identification of EphA2 ligand-binding domain binders through an optimized NMR fragment-screening workflow
2026Open Access
Cupriavidus necator, an alternative source for isotopic enrichment of proteins expressed in insect cells for NMR investigations
Journal of Biomolecular NMR·2026Open Access
Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain
ChemBioChem·2025Open Access
<scp>NMR</scp> screening of low molecular weight inhibitors targeting the papain‐like protease (<scp>PLPro</scp>) of <scp>SARS</scp>‐<scp>CoV</scp>‐2
FEBS Open Bio·2025· 1 citedOpen Access
Optimization of Structure‐Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2
Angewandte Chemie·2025Open Access
Optimization of Structure‐Guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS‐CoV‐2
Angewandte Chemie International Edition·2025· 8 citedOpen Access
The future of integrated structural biology
Structure·2024· 31 citedOpen Access
Differential effects of the N‐terminal helix of <scp>FGF</scp>8b on the activity of a small‐molecule <scp>FGFR</scp> inhibitor in cell culture and for the extracellular domain of <scp>FGFR</scp>3c in solution
FEBS Letters·2024Open Access
NMR characterization and ligand binding site of the stem loop 2 motif (s2m) from the Delta variant of SARS-CoV-2
RNA·2024· 4 citedOpen Access
Targeting the Main Protease (M<sup>pro</sup>, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies
ACS Chemical Biology·2024· 7 citedOpen Access
Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection
RSC Medicinal Chemistry·2024· 10 citedOpen Access
NMR <sup>1</sup>H,<sup>19</sup>F-based screening of the four stem-looped structure 5_SL1–SL4 located in the 5′-untranslated region of SARS-CoV 2 RNA
RSC Medicinal Chemistry·2023· 13 citedOpen Access
Targeting EPHA2 with Kinase Inhibitors in Colorectal Cancer
ChemMedChem·2023· 14 citedOpen Access
NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b
Biomolecular NMR Assignments·2023· 1 citedOpen Access
Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTnI)
Biosensors·2023· 34 citedOpen Access
Cover Feature: Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor (Chem. Eur. J. 23/2023)
Chemistry - A European Journal·2023Open Access
Graphisches Inhaltsverzeichnis: Angew. Chem. 14/2023
Angewandte Chemie·2023Open Access
Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3
Scientific Reports·2023· 18 citedOpen Access
Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor
Chemistry - A European Journal·2023· 9 citedOpen Access
Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTnI)
Preprints.org·2023· 3 citedOpen Access
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Frequent Co-authors

Harald Schwalbe(47), Krishna Saxena(25), Christian Richter(23), S.L. Gande(20), V.L. Linhard(17), D. Kudlinzki(16), Anna Wacker(10), Nadide Altincekic(10), Jasleen Kaur Bains(9), Boris Fürtig(9), Nusrat S. Qureshi(9), Julia E. Weigand(8), Jan Ferner(8), Frank Löhr(8), Andreas Schlundt(8), Maria A. Wirtz Martin(8), Jens Wöhnert(8), Hannes Berg(8), Betül Ceylan(7), Martin Hengesbach(7)