Irene N. Uzinskas

Medicine · Health Sciences

12h-index809citations20works0.02yr avg
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Research Topics

Cell Adhesion Molecules Research(5), Antimicrobial Peptides and Activities(3), Antimicrobial agents and applications(3), Antibiotic Resistance in Bacteria(2), Protease and Inhibitor Mechanisms(2)

Publications20 total

CCDC 186477: Experimental Crystal Structure Determination
The Cambridge Structural Database·2005Open Access
Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
Bioorganic & Medicinal Chemistry Letters·2003· 27 citedOpen Access
Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
Journal of Medicinal Chemistry·2003· 161 citedOpen Access
Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents
Antimicrobial Agents and Chemotherapy·2002· 163 citedOpen Access
Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)
Journal of Medicinal Chemistry·2002· 109 citedOpen Access
DISCOVERY OF AMINOPYRIDINE-BASED INHIBITIORS OF BACTERIAL ENOYL-ACP REDUCTASE (FABI)
Molecular Cell·2002
Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic
Journal of Medicinal Chemistry·1999· 116 citedOpen Access
Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics
Bioorganic & Medicinal Chemistry Letters·1999· 30 citedOpen Access
Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists
Journal of Medicinal Chemistry·1999· 53 citedOpen Access
Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists
Bioorganic & Medicinal Chemistry Letters·1998· 24 citedOpen Access
Use of X-ray Co-crystal Structures and Molecular Modeling To Design Potent and Selective Non-peptide Inhibitors of Cathepsin K
Journal of the American Chemical Society·1998· 35 cited
The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists
Advanced Drug Delivery Reviews·1997· 3 cited
Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series
Bioorganic & Medicinal Chemistry Letters·1996· 6 cited
ChemInform Abstract: Tetrahydrothiadiazoloisoquinolines: Synthesis and Inhibition of Phenylethanolamine‐N‐methyltransferase.
ChemInform·1989
Tetrahydro thiadiazolo isoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase
Journal of Medicinal Chemistry·1989· 18 citedOpen Access
ChemInform Abstract: Synthesis and Structure‐Activity Relationship Studies of a Series of 5‐Aryl‐4,6‐dithianonanedioic Acids and Related Compounds: A Novel Class of Leukotriene Antagonists.
ChemInform·1987
Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists
Journal of Medicinal Chemistry·1986· 36 citedOpen Access
Synthesis and LTD4-antagonist activity of desamino-2-nor-leukotriene analogs
Prostaglandins·1985· 11 cited
ChemInform Abstract: DIMETHYLEICOSATRIENOIC ACIDS: INHIBITORS OF THE 5‐LIPOXYGENASE ENZYME
Chemischer Informationsdienst·1983
Dimethyleicosatrienoic acids: Inhibitors of the 5-lipoxygenase enzyme
Tetrahedron Letters·1983· 17 cited

Frequent Co-authors

Catherine Yuan(9), William E. Bondinell(9), William H. Miller(8), William F. Huffman(8), Kenneth A. Newlander(7), Dirk A. Heerding(6), Karl F. Erhard(6), Chet Kwon(6), James M. Samanen(6), R. Curtis Haltiwanger(6), Shing‐Mei Hwang(6), Peter J. Manley(5), Dennis T. Takata(5), Dalia R. Jakas(5), Raul R. Calvo(5), Richard M. Keenan(5), Carl D. Perchonock(5), John G. Gleason(5), Walter J. Burgess(4), Martha S. Head(4)