Kenneth A. Newlander

GlaxoSmithKline (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.5kcitations27works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(12), Cell Adhesion Molecules Research(5), Monoclonal and Polyclonal Antibodies Research(5), Antimicrobial Peptides and Activities(5), Antimicrobial agents and applications(5)

Publications27 total

Abstract 5379: A potent EZH2 inhibitor exhibits long residence time and anti-tumor activity
Cancer Research·2015
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2
ACS Medicinal Chemistry Letters·2012· 373 citedOpen Access
Solid phase synthesis of cyclic homodetic peptide libraries utilizing a novel intraresin chain transfer
Kluwer Academic Publishers eBooks·2005
Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
Journal of Medicinal Chemistry·2003· 161 citedOpen Access
Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of<i>Staphylococcus aureus</i>
Antimicrobial Agents and Chemotherapy·2002· 96 citedOpen Access
Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents
Antimicrobial Agents and Chemotherapy·2002· 163 citedOpen Access
Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)
Journal of Medicinal Chemistry·2002· 109 citedOpen Access
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents
Bioorganic & Medicinal Chemistry Letters·2001· 62 citedOpen Access
Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic
Journal of Medicinal Chemistry·1999· 116 citedOpen Access
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model
Bioorganic & Medicinal Chemistry Letters·1999· 35 citedOpen Access
Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists
Journal of Medicinal Chemistry·1999· 53 citedOpen Access
Simple Silyl Linker for the Solid Phase Organic Synthesis of Aryl- Containing Molecules
The Journal of Organic Chemistry·1997· 50 cited
The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists
Advanced Drug Delivery Reviews·1997· 3 cited
Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series
Bioorganic & Medicinal Chemistry Letters·1996· 6 cited
Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists
Journal of Medicinal Chemistry·1996· 72 citedOpen Access
Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist
Tetrahedron Letters·1995· 49 cited
A Check on Rational Drug Design: Crystal Structure of a Complex of Human Immunodeficiency Virus Type 1 Protease with a Novel .gamma.-Turn Mimetic Inhibitor
Journal of Medicinal Chemistry·1995· 37 citedOpen Access
Synthesis of a 2-benzazepine analog of a potent, nonpeptide GPIIb/IIIa antagonist
Tetrahedron Letters·1995· 16 cited
The use of γ-turn mimetics to define peptide secondary structure
Tetrahedron·1993· 48 cited
A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the systematic incorporation of γ-turn mimetics into a model substrate
1993
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Frequent Co-authors

William F. Huffman(18), James F. Callahan(13), William H. Miller(10), M. Lane Moore(8), Irene N. Uzinskas(7), Dalia R. Jakas(7), William E. Bondinell(7), Raul R. Calvo(6), Richard M. Keenan(6), James M. Samanen(6), David Payne(5), Walter E. DeWolf(5), Terrance Moore(5), Stephen Rittenhouse(5), Mark A. Seefeld(5), Dennis T. Takata(5), R. Curtis Haltiwanger(5), Thomas W. Ku(5), Drake S. Eggleston(5), Joelle L. Burgess(4)