Charles Harris

Regeneron (United States) — United States

Medicine · Health Sciences

32h-index6.5kcitations79works8.02yr avg
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Research Topics

Adipose Tissue and Metabolism(21), Adipokines, Inflammation, and Metabolic Diseases(12), Hormonal Regulation and Hypertension(11), Estrogen and related hormone effects(8), Liver Disease Diagnosis and Treatment(6)

Publications78 total

Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first‐in‐human phase I study
Clinical and Translational Science·2024· 8 citedOpen Access
FRI059 Long-term Follow-up On Partial Lipodystrophy Treated With Leptin Receptor Agonist Mibavademab(REGN4461)
Journal of the Endocrine Society·2023· 1 citedOpen Access
FRI058 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Metabolic Parameters In Individuals With Generalized Lipodystrophy
Journal of the Endocrine Society·2023· 1 citedOpen Access
FRI069 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Weight And Associated Comorbidities In Congenital Leptin Deficiency
Journal of the Endocrine Society·2023Open Access
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes
Nature Communications·2022· 49 citedOpen Access
Qualitative interviews in patients with lipodystrophy to assess the patient experience: evaluation of hunger and other symptoms
Journal of Patient-Reported Outcomes·2022· 8 citedOpen Access
Leptin mediates the regulation of muscle mass and strength by adipose tissue
The Journal of Physiology·2022· 50 citedOpen Access
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
eLife·2021· 46 citedOpen Access
Author response: A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
2021Open Access
Taxonomic changes in the gut microbiota are associated with cartilage damage independent of adiposity, high fat diet, and joint injury
Scientific Reports·2021· 20 citedOpen Access
Taxonomic changes in the microbiota are associated with cartilage damage in a mouse model of high-fat diet and OA
Osteoarthritis and Cartilage·2021Open Access
Fat implantation in lipodystrophic mice restores susceptibility to joint injury and osteoarthritis independent of body weight
Osteoarthritis and Cartilage·2021· 1 citedOpen Access
A novel skeletal-specific adipogenesis pathway defines key origins and adaptations of bone marrow adipocytes with age and disease
2021· 2 citedOpen Access
Adipose tissue is a critical regulator of osteoarthritis
Proceedings of the National Academy of Sciences·2020· 188 citedOpen Access
Hepatic lipids promote liver metastasis
JCI Insight·2020· 49 citedOpen Access
Adipose Tissue is a Critical Regulator of Osteoarthritis
2020· 13 citedOpen Access
Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction
The Journal of Physiology·2020· 198 citedOpen Access
SAT-588 Role of Adipose Tissue in Reproduction, Mammary Gland Development, Function and Cancer
Journal of the Endocrine Society·2020Open Access
Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling
Scientific Reports·2019· 30 citedOpen Access
Epithelial-adipocyte interactions are required for mammary gland development, but not for milk production or fertility
Developmental Biology·2019· 25 citedOpen Access
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Frequent Co-authors

Irina Hutson(8), Jen-Chywan Wang(6), Robert V. Farese(5), Kelsey H. Collins(5), Daniel Ferguson(5), Steven L. Teitelbaum(5), Eugene M. Johnson(4), Gretchen A. Meyer(4), Kristin L. Lenz(4), Farshid Guilak(4), Erica L. Scheller(4), Eva Herker(3), Mélanie Ott(3), Taiyi Kuo(3), Christine T. N. Pham(3), Nidhi Rohatgi(3), Jonathan R. Brestoff(3), Wei Zou(3), Clarissa S. Craft(3), Kevin T. Bauerle(3)