Paul Beroza

Computer Science · Physical Sciences

26h-index2.6kcitations51works1.62yr avg
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Research Topics

Computational Drug Discovery Methods(17), Spectroscopy and Quantum Chemical Studies(10), Hippo pathway signaling and YAP/TAZ(10), Protein Structure and Dynamics(9), Photosynthetic Processes and Mechanisms(9)

Publications51 total

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2024· 2 citedOpen Access
Author response: Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2024Open Access
Shape-Aware Synthon Search (SASS) for Virtual Screening of Synthon-Based Chemical Spaces
Journal of Chemical Information and Modeling·2024· 9 cited
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2024· 1 citedOpen Access
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2024· 1 citedOpen Access
Reviewer #3 (Public Review): Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2024Open Access
Reviewer #2 (Public Review): Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2024Open Access
Reviewer #1 (Public Review): Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2024Open Access
Autoregressive fragment-based diffusion for pocket-aware ligand design
arXiv (Cornell University)·2023· 5 citedOpen Access
Shape-Aware Synthon Search (SASS) for virtual screening of synthon-based chemical spaces
2023· 2 citedOpen Access
Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation
2023Open Access
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance
Nature Cancer·2023· 170 citedOpen Access
Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Nature Communications·2022· 102 citedOpen Access
Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling
Cell Reports·2020· 161 citedOpen Access
Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450–Catalyzed Radical Coupling
Drug Metabolism and Disposition·2020· 8 citedOpen Access
Including Explicit Water Molecules as Part of the Protein Structure in MM/PBSA Calculations
Journal of Chemical Information and Modeling·2013· 41 cited
Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors
Biochemical and Biophysical Research Communications·2013· 6 cited
Correction: Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target
PLoS ONE·2013Open Access
Improved Ligand Binding Energies Derived from Molecular Dynamics: Replicate Sampling Enhances the Search of Conformational Space
Journal of Chemical Information and Modeling·2013· 28 cited
Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target
PLoS ONE·2013· 19 citedOpen Access
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Frequent Co-authors

James J. Crawford(11), Jennifer E. Klomp(10), Jennifer A. Lacap(10), Cameron L. Noland(10), Saundra Clausen(10), Wendy Lee(10), Rina Fong(10), Thijs J. Hagenbeek(9), Xiaosai Yao(9), Scott E. Martin(9), Marta H. Kubala(9), Maria Lorenzo(9), Ho-June Lee(9), Trang H. Pham(9), Zora Modrušan(9), Jason Li(9), Matthew T. Chang(9), Xin Ye(9), Anwesha Dey(9), Kanika Bajaj Pahuja(8)