Daniel Spinks

Wellcome Centre for Anti-Infectives Research — United Kingdom

Medicine · Health Sciences

18h-index1.2kcitations35works0.02yr avg
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Research Topics

Trypanosoma species research and implications(17), Research on Leishmaniasis Studies(14), Synthesis and Biological Evaluation(11), Biochemical and Molecular Research(5), Chemical Synthesis and Analysis(4)

Publications35 total

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
Journal of Medicinal Chemistry·2023· 6 citedOpen Access
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent <i>In Vitro</i> Antileishmanial Activity: Initial SAR and Assessment of <i>In Vivo</i> Activity
Journal of Medicinal Chemistry·2020· 12 citedOpen Access
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
Proceedings of the National Academy of Sciences·2019· 165 citedOpen Access
CCDC 1857125: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1857128: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
Journal of Medicinal Chemistry·2018· 48 citedOpen Access
2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease
Bioorganic & Medicinal Chemistry Letters·2018· 5 citedOpen Access
Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal·2017· 18 citedOpen Access
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against <i>Trypanosoma cruzi</i>
Journal of Medicinal Chemistry·2017· 43 citedOpen Access
Cover Picture: Development of Small‐Molecule <i>Trypanosoma brucei N</i>‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015)
ChemMedChem·2015
Development of Small‐Molecule <i>Trypanosoma brucei N</i>‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
ChemMedChem·2015· 22 citedOpen Access
Design, Synthesis and Biological Evaluation of <i>Trypanosoma brucei</i> Trypanothione Synthetase Inhibitors
ChemMedChem·2011· 44 citedOpen Access
Discovery of a Novel Class of Orally Active Trypanocidal <i>N</i>-Myristoyltransferase Inhibitors
Journal of Medicinal Chemistry·2011· 115 citedOpen Access
Optimisation of the Anti‐<i>Trypanosoma brucei</i> Activity of the Opioid Agonist U50488
ChemMedChem·2011· 8 citedOpen Access
Cover Picture: Synthesis and Evaluation of Indatraline‐Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of <i>Trypanosoma brucei</i> Pteridine Reductase 1 / Modified 5′‐Trityl Nucleosides as Inhibitors of <i>Plasmodium falciparum</i> dUTPase (ChemMedChem 2/2011)
ChemMedChem·2011Open Access
Design, Synthesis and Biological Evaluation of Novel Inhibitors of <i>Trypanosoma brucei</i> Pteridine Reductase 1
ChemMedChem·2010· 45 citedOpen Access
A high-throughput in vitro screen to identify inhibitors of the trypanosoma brucei trypananthione synthethase activity
American Journal of Tropical Medicine and Hygiene·2010
The discovery and SAR of indoline-3-carboxamides—A new series of 5-HT6 antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
Investigation of Trypanothione Reductase as a Drug Target in <i>Trypanosoma brucei</i>
ChemMedChem·2009· 57 citedOpen Access
Chemical Validation of Trypanothione Synthetase
Journal of Biological Chemistry·2009· 79 citedOpen Access
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Frequent Co-authors

Paul G. Wyatt(21), Ian H. Gilbert(20), Kevin D. Read(15), Alan H. Fairlamb(13), Julie A. Frearson(13), Laste Stojanovski(10), Suzanne Norval(9), Ruth Brenk(9), Stephen Brand(8), Manu De Rycker(8), David A. Robinson(8), Victoria Smith(8), Iain T. Collie(8), Michael G. Thomas(7), Jennifer Riley(7), Frederick R. C. Simeons(7), Laura A. T. Cleghorn(7), Maria Osuna‐Cabello(6), Stephen Thompson(6), José M. Fiandor(6)