John J. Fak

Rockefeller University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index10.2kcitations72works20.02yr avg
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Research Topics

RNA Research and Splicing(35), RNA modifications and cancer(20), RNA and protein synthesis mechanisms(16), Cancer-related molecular mechanisms research(11), RNA regulation and disease(8)

Publications72 total

Genetic mapping identifies Homer1 as a developmental modifier of attention
Nature Neuroscience·2025Open Access
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Nature Neuroscience·2024· 40 citedOpen Access
Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson’s disease
Nature Communications·2023· 50 citedOpen Access
Genetic mapping identifies Homer1 as a developmental modifier of attention
2023Open Access
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Science Translational Medicine·2023· 91 citedOpen Access
Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade
Journal of Clinical Investigation·2022· 23 citedOpen Access
Transcriptome patterns and their regulation by alternative splicing in Parkinson’s disease. (P12-11.006)
Neurology·2022· 2 cited
FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
eLife·2021· 59 citedOpen Access
Author response: FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
2021· 1 citedOpen Access
FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
2021· 4 citedOpen Access
DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2
PLoS ONE·2021· 7 citedOpen Access
DRUL for School: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2
2021Open Access
RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares
New England Journal of Medicine·2020· 194 citedOpen Access
FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory
eLife·2019· 119 citedOpen Access
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
Neuron·2019· 76 citedOpen Access
Author response: FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory
2019· 2 citedOpen Access
FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types
2019· 19 citedOpen Access
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
Neuron·2019· 313 citedOpen Access
AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke
Cell Reports·2019· 27 citedOpen Access
Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk
Nature Genetics·2019· 322 citedOpen Access
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Frequent Co-authors

Robert B. Darnell(38), Christopher Y. Park(11), Aldo Mele(9), Nathalie E. Blachère(9), Michael J. Moore(7), Salina Parveen(7), Chaolin Zhang(6), Ilana Zucker-Scharff(6), Dana E. Orange(6), Kirsty Sawicka(6), Mayu O. Frank(6), Caryn Hale(6), Donny D. Licatalosi(5), Yuhki Saito(5), Joseph M. Luna(5), Charles M. Rice(5), Troels K. H. Scheel(4), Eiko Nishiuchi(4), Claudia Scheckel(4), J.F. Hunt(4)