Robert B. Darnell

Howard Hughes Medical Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

96h-index39.9kcitations303works13.52yr avg
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Research Topics

RNA Research and Splicing(124), RNA modifications and cancer(70), RNA and protein synthesis mechanisms(63), RNA regulation and disease(43), Genetics and Neurodevelopmental Disorders(42)

Publications303 total

Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency
2025Open Access
A humanized NOVA1 splicing factor alters mouse vocal communications
Nature Communications·2025· 13 citedOpen Access
ELAVL3 regulates splicing of RNAs encoding synaptic signaling proteins in D1 and D2 striatal medium spiny neurons
2024Open Access
Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation
2024· 1 citedOpen Access
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis
Science Translational Medicine·2024· 53 citedOpen Access
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Nature Neuroscience·2024· 40 citedOpen Access
Extrarenal symptoms associate with worse quality of life in patients enrolled in the AMP RA/SLE Lupus Nephritis Network
Lara D. Veeken·2024· 6 citedOpen Access
Mapping and characterization of structural variation in 17,795 human genomes
UNC Libraries·2024Open Access
NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells
Proceedings of the National Academy of Sciences·2024· 3 citedOpen Access
Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network
Arthritis Research & Therapy·2024· 19 citedOpen Access
MicroRNA-218 instructs proper assembly of hippocampal networks
eLife·2023· 14 citedOpen Access
Author response: MicroRNA-218 instructs proper assembly of hippocampal networks
2023Open Access
Machine Learning Reveals Synovial Fibroblast Genes Associated with Pain Affect Sensory Nerve Growth in Rheumatoid Arthritis
2023· 8 citedOpen Access
Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson’s disease
Nature Communications·2023· 50 citedOpen Access
Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing
eLife·2023· 12 citedOpen Access
Author response: Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing
2023· 1 citedOpen Access
Supplementary Table 5 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel <i>AKT1</i> Fusion–Driven Cancer
2023Open Access
Data from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel <i>AKT1</i> Fusion–Driven Cancer
2023Open Access
Supplementary Table 2 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel <i>AKT1</i> Fusion–Driven Cancer
2023Open Access
Supplementary Table 3 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel <i>AKT1</i> Fusion–Driven Cancer
2023Open Access
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Frequent Co-authors

Aldo Mele(11), John J. Fak(9), Jennifer C. Darnell(6), Chaolin Zhang(5), Donny D. Licatalosi(5), Jernej Ule(5), Kirk B. Jensen(5), Hirotaka James Okano(5), Claire Fraser(4), Sung Wook(4), Matteo Ruggiu(4), Giovanni Stefani(4), Jennifer C. Darnell(3), Michael J. Moore(3), Christopher Y. Park(3), Ronald J. Buckanovich(3), Michael C. Zody(3), Joseph M. Luna(3), Ivan Iossifov(2), W. Richard McCombie(2)