Sergio Lociuro

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.7kcitations50works0.02yr avg
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Research Topics

Antibiotic Resistance in Bacteria(15), Pneumocystis jirovecii pneumonia detection and treatment(9), Microbial Natural Products and Biosynthesis(7), Antimicrobial Resistance in Staphylococcus(6), Chemical Synthesis and Analysis(6)

Publications50 total

Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii
European Journal of Medicinal Chemistry·2023· 4 citedOpen Access
Targeting virulence regulation to disarm <i>Acinetobacter baumannii</i> pathogenesis
Virulence·2022· 12 citedOpen Access
Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration
European Journal of Medicinal Chemistry·2022· 7 citedOpen Access
The small-molecule SMARt751 reverses <i>Mycobacterium tuberculosis</i> resistance to ethionamide in acute and chronic mouse models of tuberculosis
Science Translational Medicine·2022· 27 citedOpen Access
Design and Synthesis of Water-Soluble Prodrugs of Rifabutin for Intraveneous Administration
SSRN Electronic Journal·2022· 1 citedOpen Access
Rifabutin for infusion (BV100) for the treatment of severe carbapenem-resistant Acinetobacter baumannii infections
Drug Discovery Today·2021· 18 cited
The Role of OmpR in Bile Tolerance and Pathogenesis of Adherent-Invasive Escherichia coli
Frontiers in Microbiology·2021· 16 citedOpen Access
<i>In vitro</i>activity of rifabutin against 293 contemporary carbapenem-resistant<i>Acinetobacter baumannii</i>clinical isolates and characterization of rifabutin mode of action and resistance mechanisms
Journal of Antimicrobial Chemotherapy·2020· 34 citedOpen Access
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
Nature Communications·2020· 181 citedOpen Access
A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii
Nature Microbiology·2020· 72 citedOpen Access
Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates
mBio·2019· 129 citedOpen Access
A Novel Genome-Editing Platform for Drug-Resistant Acinetobacter baumannii Reveals an AdeR-Unrelated Tigecycline Resistance Mechanism
Antimicrobial Agents and Chemotherapy·2016· 48 citedOpen Access
Synthesis and Structure–Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics
ACS Medicinal Chemistry Letters·2014· 22 cited
A microdose study of 14C-AR-709 in healthy men: pharmacokinetics, absolute bioavailability and concentrations in key compartments of the lung
European Journal of Clinical Pharmacology·2013· 18 cited
4″-O-(ω-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens
Bioorganic & Medicinal Chemistry·2010· 30 cited
In Vitro Bactericidal Activity of Iclaprim in Human Plasma
Antimicrobial Agents and Chemotherapy·2009· 20 citedOpen Access
Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from<i>Staphylococcus aureus</i>
Acta Crystallographica Section D Biological Crystallography·2009· 44 cited
Efficacy of Iclaprim against Wild-Type and Thymidine Kinase-Deficient Methicillin-Resistant <i>Staphylococcus aureus</i> Isolates in an In Vitro Fibrin Clot Model
Antimicrobial Agents and Chemotherapy·2009· 8 citedOpen Access
Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity
Journal of Antimicrobial Chemotherapy·2009· 105 cited
Antistreptococcal Activity of AR-709 Compared to That of Other Agents
Antimicrobial Agents and Chemotherapy·2008· 5 citedOpen Access
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Frequent Co-authors

Vincent Trebosc(10), Marc Gitzinger(10), Christian Kemmer(9), Glenn E. Dale(8), Daniele Andreotti(8), Birgit Schellhorn(7), Stefano Biondi(7), Stephen Hawser(6), Paolo Tavecchia(6), Marilyne Bourotte(6), Daniele Donati(6), Khalid Islam(5), Enrico Selva(5), Riccardo Bonfichi(5), Romeo Ciabatti(5), Valentina Lucchini(4), Michel Pieren(4), Heike Laue(4), Michael Kurz(4), Nicolas Willand(4)