James L. Manley

Columbia University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

121h-index48.8kcitations421works3.42yr avg
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Research Topics

RNA Research and Splicing(277), RNA and protein synthesis mechanisms(158), RNA modifications and cancer(148), Genomics and Chromatin Dynamics(54), Virus-based gene therapy research(36)

Publications416 total

Multiple human enhancer RNAs contain long translated open reading frames
Genes & Development·2025· 1 citedOpen Access
SUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer
Cell Reports·2025· 2 citedOpen Access
Multiple human enhancer RNAs contain long translated open reading frames
2025Open Access
Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
Protocol for detection of cGAMP-induced STING oligomerization in cultured cells
STAR Protocols·2025· 1 citedOpen Access
SUGP1 loss is the sole driver of SF3B1 hotspot mutant missplicing in cancer
2025Open Access
SF3B1: from core splicing factor to oncogenic driver
RNA·2025· 8 citedOpen Access
Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing
2024· 1 citedOpen Access
Splicing dysregulation in glioblastoma alters the function of cell migration‐related genes
Glia·2024· 4 citedOpen Access
Splicing dysregulation in glioblastoma alters the function of cell migration-related genes
2024· 1 citedOpen Access
<i>WDR33</i> alternative polyadenylation is dependent on stochastic poly(a) site usage and splicing efficiencies
RNA Biology·2024· 2 citedOpen Access
Modulation of diverse biological processes by CPSF, the master regulator of mRNA 3′ ends
RNA·2024· 7 citedOpen Access
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
Blood Advances·2024· 7 citedOpen Access
Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
Cell Reports·2024· 11 citedOpen Access
Characterization of the SF3B1–SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing
Genes & Development·2023· 20 citedOpen Access
OC-0430 Class I histone deacetylase inhibitor Entinostat sensitises prostate cancer cells to radiation
Radiotherapy and Oncology·2023
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
2023· 1 citedOpen Access
A nucleolar long “non-coding” RNA encodes a novel protein that functions in response to stress
Proceedings of the National Academy of Sciences·2023· 19 citedOpen Access
Terri Grodzicker and the making of<i>Genes &amp; Development</i>
Genes & Development·2023Open Access
DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer
Proceedings of the National Academy of Sciences·2022· 46 citedOpen Access
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Frequent Co-authors

Mo Chen(3), Bin Tian(3), Michael Levine(3), Kanneganti Murthy(3), Andrew Fire(2), Phillip A. Sharp(2), Charles J. David(2), Liang Tong(2), Xialu Li(2), Dafne Campigli Di Giammartino(2), Roland Tacke(2), Ping Zuo(2), Yutaka Hirose(2), Yongsheng Shi(2), Hui Ge(2), Kyuhyung Han(2), Yoshio Takagaki(2), Jian Zhang(2), Amparo Cano(1), M L Gefter(1)