Mikko Taipale

University of Toronto — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index11.4kcitations100works16.62yr avg
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Research Topics

Genomics and Chromatin Dynamics(18), Heat shock proteins research(14), Ubiquitin and proteasome pathways(14), Protein Structure and Dynamics(12), CRISPR and Genetic Engineering(12)

Publications99 total

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
2025Open Access
Comprehensively Testing the Function of Missense Variation in the <i>STK11</i> Tumour Suppressor
2025Open Access
What is the current bottleneck in mapping molecular interaction networks?
Cell Systems·2025Open Access
Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters
npj Viruses·2025· 2 citedOpen Access
The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations
Journal of Cell Science·2024· 4 cited
Pervasive mislocalization of pathogenic coding variants underlying human disorders
Cell·2024· 39 citedOpen Access
An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies
EMBO Molecular Medicine·2024· 5 citedOpen Access
An HSF1–JMJD6–HSP feedback circuit promotes cell adaptation to proteotoxic stress
Proceedings of the National Academy of Sciences·2024· 5 citedOpen Access
Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25
Molecular Cell·2024· 22 cited
Enhanced delivery of protein therapeutics with a diphtheria toxin-like platform that evades pre-existing neutralizing immunity
2024Open Access
Proteome-scale discovery of protein degradation and stabilization effectors
Nature·2024· 69 cited
CROPseq-multi: a universal solution for multiplexed perturbation in high-content pooled CRISPR screens
2024· 18 citedOpen Access
The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations
2024· 2 citedOpen Access
Pervasive mislocalization of pathogenic coding variants underlying human disorders
2023· 9 citedOpen Access
<scp>PP2A</scp> ‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells
Molecular Oncology·2023· 8 citedOpen Access
Author response for "&lt;scp&gt;PP2A&lt;/scp&gt;‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells"
2023
Author response for "&lt;scp&gt;PP2A&lt;/scp&gt;‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells"
2023
A central chaperone-like role for 14-3-3 proteins in human cells
Molecular Cell·2023· 68 citedOpen Access
A universal deep-learning model for zinc finger design enables transcription factor reprogramming
Nature Biotechnology·2023· 83 citedOpen Access
Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors
Heliyon·2022· 24 citedOpen Access
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Frequent Co-authors

Anne‐Claude Gingras(12), Susan Lindquist(11), Nader Alerasool(8), Irina Krykbaeva(6), Mandy Hiu Yi Lam(6), Asifa Akhtar(6), Jessica Lacoste(6), Jian Peng(5), Frederick P. Roth(5), Marc Vidal(5), Brett Larsen(5), Juha Kere(5), Timothy R. Hughes(4), Michael A. Calderwood(4), David E. Hill(4), Jaana Nopola‐Hemmi(4), Katariina Hannula‐Jouppi(4), Zhen‐Yuan Lin(4), Hunsang Lee(4), Daniel Schramek(4)