Florent Laferrière

Centre National de la Recherche Scientifique — France

Medicine · Health Sciences

14h-index1.2kcitations37works8.72yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(15), Prion Diseases and Protein Misfolding(15), Alzheimer's disease research and treatments(12), Amyotrophic Lateral Sclerosis Research(8), Neurological diseases and metabolism(8)

Publications37 total

Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Nature·2025· 4 citedOpen Access
Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils
EMPIAR dataset·2025Open Access
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
2024· 5 citedOpen Access
Cryo-EM images of alpha-synuclein fibrils «1B» capable of seeding GCI in vivo
EMPIAR dataset·2024Open Access
Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
Translational Neurodegeneration·2024Open Access
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
Nature·2024· 51 citedOpen Access
Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Research Square (Research Square)·2024· 1 citedOpen Access
Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?
Biomolecules·2023· 14 citedOpen Access
Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Biomolecules·2022· 12 citedOpen Access
Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
npj Parkinson s Disease·2022· 35 citedOpen Access
Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
2021· 13 citedOpen Access
Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson’s disease brains
2021· 1 citedOpen Access
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
Cells·2020· 19 citedOpen Access
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Science Advances·2020· 79 citedOpen Access
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
Science Advances·2020· 58 citedOpen Access
Crossing Species Barriers Relies on Structurally Distinct Prion Assemblies and Their Complementation
Molecular Neurobiology·2020· 14 citedOpen Access
Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts
Biomolecules·2020· 71 citedOpen Access
Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
2020· 2 citedOpen Access
Complementation between pathological prion protein subassemblies to cross existing species barriers
2019Open Access
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
2019· 5 citedOpen Access
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Frequent Co-authors

Francesca De Giorgi(15), François Ichas(15), Erwan Bézard(15), Laëtitia Herzog(10), Vincent Béringue(10), Fabienne Reine(9), Magdalini Polymenidou(8), Marie-Laure Arotçarena(8), Mohammed Moudjou(8), Antoine Loquet(7), Human Rézaei(7), Francesco De Nuccio(7), Marianna Kashyrina(7), Dario Domenico Lofrumento(7), Philippe Tixador(6), Angélique Igel‐Egalon(6), Eva‐Maria Hock(5), Zuzanna Maniecka(5), Marián Hruška-Plocháň(5), Henning Stahlberg(5)