Marián Hruška-Plocháň

University of Zurich — Switzerland

Medicine · Health Sciences

18h-index1.4kcitations39works23.72yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(14), RNA Research and Splicing(7), Genetic Neurodegenerative Diseases(7), Neurogenetic and Muscular Disorders Research(7), Nerve injury and regeneration(6)

Publications39 total

Blocking RAN translation without altering repeat RNAs rescues <i>C9ORF72</i> -related ALS and FTD phenotypes
Science·2026· 1 cited
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures
Neuron·2025· 19 citedOpen Access
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
Nature·2024· 51 citedOpen Access
Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns
The EMBO Journal·2023· 82 citedOpen Access
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of <i>C9orf72</i> disease
Proceedings of the National Academy of Sciences·2022· 8 citedOpen Access
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation
The EMBO Journal·2022· 9 citedOpen Access
Author Reply to Peer Reviews of An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
2022
TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies
2022· 5 citedOpen Access
An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation
2022· 3 citedOpen Access
Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease
2022Open Access
Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD
2021· 13 citedOpen Access
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
EMBO Molecular Medicine·2021· 75 citedOpen Access
Targeted mass spectrometry for monitoring of neural differentiation
Biology Open·2021· 3 citedOpen Access
Author Reply to Peer Reviews of LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
2021
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
Nature Communications·2021· 71 citedOpen Access
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
2021· 5 citedOpen Access
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
Cell Reports·2020· 118 citedOpen Access
Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice
2020· 2 citedOpen Access
Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells
Nature Genetics·2019· 35 citedOpen Access
A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors
Stem Cell Research & Therapy·2019· 43 citedOpen Access
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Frequent Co-authors

Magdalini Polymenidou(20), Martin Maršala(14), Adriano Aguzzi(10), Manuela Pérez‐Berlanga(9), Štefan Juhás(9), Jana Juhásová(9), Pierre De Rossi(9), Silvia Marsala(8), Elena Tantardini(8), Jan Motlík(7), Zuzanna Maniecka(6), Atsushi Miyanohara(6), Sonu Sahadevan(6), Marc Emmenegger(6), Merve Avar(6), Daniel Heinzer(6), Simone Hornemann(6), Dáša Bohačiaková(6), Florent Laferrière(5), Tammaryn Lashley(5)