Yanai Zhan

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.4kcitations25works0.02yr avg
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Research Topics

Protein Degradation and Inhibitors(9), Chromatin Remodeling and Cancer(8), Cancer Mechanisms and Therapy(8), Neuropeptides and Animal Physiology(7), Helicobacter pylori-related gastroenterology studies(4)

Publications25 total

Data from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
2023Open Access
Supplementary Figures 1 - 8 from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
2023Open Access
Supplementary Figures 1 - 8 from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
2023Open Access
Supplementary Methods, Figure Legends from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
2023Open Access
Supplementary Methods, Figure Legends from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
2023Open Access
Data from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
2023Open Access
MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway.
PubMed·2018· 58 cited
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery
Epigenetics & Chromatin·2015· 40 citedOpen Access
Abstract 3528: The SMARCA2/4 catalytic activity, but not the bromodomain, is a drug target in SWI/SNF mutant cancers
Cancer Research·2015
The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
Cancer Research·2015· 266 citedOpen Access
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor
Journal of Medicinal Chemistry·2015· 152 citedOpen Access
Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2
Biochemical Journal·2014· 37 citedOpen Access
Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer
Molecular Therapy·2014· 192 citedOpen Access
C-Met Inhibitor MK-8003 Radiosensitizes c-Met–Expressing Non–Small-Cell Lung Cancer Cells With Radiation-Induced c-Met–Expression
Journal of Thoracic Oncology·2012· 72 citedOpen Access
Abstract 1099: MiR-200c overexpression radiosensitizes lung cancer cells
Cancer Research·2012
Insulin-like Growth Factor-1 Receptor Transactivation Modulates the Inflammatory and Proliferative Responses of Neurotensin in Human Colonic Epithelial Cells
Journal of Biological Chemistry·2011· 48 citedOpen Access
Control of Cell Growth and Survival by Enzymes of the Fatty Acid Synthesis Pathway in HCT-116 Colon Cancer Cells
Clinical Cancer Research·2008· 68 cited
Kinetic analysis of the fatty acid synthesis pathway in HCT-116 colon cancer cells: role of FAS and ACC1 in maintaining tumor cell viability and proliferation
Cancer Research·2007· 2 cited
Substance P mediates antiapoptotic responses in human colonocytes by Akt activation
Proceedings of the National Academy of Sciences·2007· 103 citedOpen Access
Neurotensin stimulates expression of early growth response gene‐1 and EGF receptor through MAP kinase activation in human colonic epithelial cells
International Journal of Cancer·2007· 37 citedOpen Access
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Frequent Co-authors

Xi Shi(11), Elisabetta Leo(11), Wylie S. Palmer(11), Jannik N. Andersen(11), Trang N. Tieu(10), Carlo Toniatti(10), Alessia Petrocchi(10), Giulio Draetta(10), Bhavatarini Vangamudi(9), Maria Kost‐Alimova(9), Timothy P. Heffernan(9), Joseph R. Marszalek(9), Thomas A. Paul(8), Parantu K. Shah(8), Lisa Nottebaum(8), Harshad S. Mahadeshwar(8), Alexei Protopopov(8), P. Andrew Futreal(8), Mike Peoples(8), Dominique Verhelle(8)