K.L. Kavanagh

University of Oxford — United Kingdom

Materials Science · Physical Sciences

36h-index6.0kcitations182works0.02yr avg
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Research Topics

Enzyme Structure and Function(33), Biochemical and Molecular Research(25), Metabolism and Genetic Disorders(22), Diet, Metabolism, and Disease(22), Bone health and treatments(18)

Publications182 total

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase
ACS Catalysis·2019· 16 citedOpen Access
Deviant Peer Involvement Measure
PsycTESTS Dataset·2016
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
Bone·2015· 62 citedOpen Access
Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure–activity relationships
Chemico-Biological Interactions·2014· 34 cited
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
Nature·2014· 101 citedOpen Access
The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
2013
Crystal structure of human GDP-L-fucose synthase with bound NADP and product GDP-L-fucose
2013
Crystal structure of human GDP-L-fucose synthase with bound NADP
2013
Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form
2012
Crystal Structure of human epimerase family protein SDR39U1 (isoform2) with NADPH
2012
Structure and Mechanism of Human UDP-xylose Synthase
Journal of Biological Chemistry·2012· 46 citedOpen Access
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family
BMC Structural Biology·2012· 36 citedOpen Access
CCDC 782890: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid
Oxford University Research Archive (ORA) (University of Oxford)·2012· 1 cited
CCDC 782886: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
CCDC 782887: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
Journal of Biological Chemistry·2011· 30 citedOpen Access
Words in a Cultural Context?
SHILAP Revista de lepidopterología·2011Open Access
Structure and mechanism of oxidoreductases providing precursors to human glycosaminoglycan biosynthesis: UDP-glucose dehydrogenase and UDP-xylose synthase
2011
Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis
Archives of Biochemistry and Biophysics·2011· 12 cited
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Frequent Co-authors

Udo Oppermann(36), Bernd Nidetzky(14), David K. Wilson(10), Mario Klimacek(8), F. von Delft(7), James E. Dunford(6), R.G.G. Russell(6), M.A. McDonough(6), Christopher J. Schofield(6), Frank H. Ebetino(5), Ewa S. Pilka(5), Wen‐Hwa Lee(5), Xiaoqiu Wu(4), O. Gileadi(4), Grazyna Kochan(4), T. Krojer(4), Petra Lukacik(4), G. Bunkóczi(4), Wyatt W. Yue(4), Sigrid Egger(4)