Zexiang Chen

The University of Texas Southwestern Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index652citations22works14.82yr avg
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Research Topics

CRISPR and Genetic Engineering(15), RNA Interference and Gene Delivery(8), Advanced biosensing and bioanalysis techniques(7), Cytomegalovirus and herpesvirus research(4), Virus-based gene therapy research(3)

Publications22 total

Publisher Correction: High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics
Nature Materials·2025· 5 citedOpen Access
High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics
Nature Materials·2025· 36 cited
Rational Design of Enhanced Nme2Cas9 and Nme2 <sup>Smu</sup> Cas9 Nucleases and Base Editors
2024Open Access
Increasing intracellular dNTP levels improves prime editing efficiency
Nature Biotechnology·2024· 18 citedOpen Access
<i>In Vivo</i> Prime Editing by Lipid Nanoparticle Co-Delivery of Chemically Modified pegRNA and Prime Editor mRNA
GEN Biotechnology·2023· 23 citedOpen Access
A Fluorescent Reporter Mouse for <i>In Vivo</i> Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors
The CRISPR Journal·2023· 5 citedOpen Access
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing <i>in vivo</i>
Nucleic Acids Research·2023· 14 citedOpen Access
Addressing the dNTP bottleneck restricting prime editing activity
2023· 8 citedOpen Access
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates
Nature Biotechnology·2023· 54 citedOpen Access
Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag
Nature Methods·2023· 64 citedOpen Access
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing <i>in vivo</i>
2023· 1 citedOpen Access
Study on adsorption characteristics of radioactive gaseous iodine on Ag ion exchange molecular sieve
Journal of Radioanalytical and Nuclear Chemistry·2023· 6 cited
Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing
ACS Chemical Biology·2022· 8 citedOpen Access
A split prime editor with untethered reverse transcriptase and circular RNA template
Nature Biotechnology·2022· 156 cited
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo
Nature Communications·2021· 110 citedOpen Access
5′-Modifications improve potency and efficacy of DNA donors for precision genome editing
eLife·2021· 71 citedOpen Access
Author response: 5′-Modifications improve potency and efficacy of DNA donors for precision genome editing
2021Open Access
5′ Modifications Improve Potency and Efficacy of DNA Donors for Precision Genome Editing
2018· 17 citedOpen Access
Effect of Sodium Ions on RNA Duplex Stability
Biochemistry·2013· 29 citedOpen Access
Fabrication and field emission characteristics of LaB6 field-emitter arrays
High Power Laser and Particle Beams·2008
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Frequent Co-authors

Erik J. Sontheimer(15), Jonathan K. Watts(11), Scot A. Wolfe(6), Pengpeng Liu(6), Karen Kelly(6), Wen Xue(5), Aamir Mir(5), Nathan D. Lawson(5), Haoyang Cheng(4), Guangping Gao(4), Krishna S. Ghanta(4), Xiaolong Dong(3), Shun‐Qing Liang(3), Gregoriy A. Dokshin(3), Pranathi M. Krishnamurthy(3), Yeonsoo Yoon(3), Judith Gallant(3), Ping Xu(3), Xiao‐Ou Zhang(3), Masahiro Shin(3)