Menno van Lummel

Leiden University Medical Center — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.8kcitations38works0.02yr avg
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Research Topics

Diabetes and associated disorders(16), Immune Cell Function and Interaction(13), T-cell and B-cell Immunology(8), Systemic Lupus Erythematosus Research(8), Pancreatic function and diabetes(8)

Publications38 total

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes
Diabetologia·2019· 32 citedOpen Access
Ligandomes obtained from different HLA-class II-molecules are homologous for N- and C-terminal residues outside the peptide-binding cleft
Immunogenetics·2019· 6 citedOpen Access
Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes
Diabetes·2019· 25 citedOpen Access
Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes
Nature Medicine·2017· 232 citedOpen Access
A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes
Current Opinion in Immunology·2016· 46 citedOpen Access
Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis
Current Diabetes Reports·2016· 35 citedOpen Access
Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR
The Journal of Immunology·2016· 32 cited
Human islets and dendritic cells generate post-translationally modified islet autoantigens
Clinical & Experimental Immunology·2016· 48 citedOpen Access
Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8<i>trans</i> Molecule
Diabetes·2015· 44 citedOpen Access
An Arthritis‐Suppressive and Treg Cell–Inducing CD4+ T Cell Epitope Is Functional in the Context of HLA‐Restricted T Cell Responses
Arthritis & Rheumatology·2015· 23 cited
Faculty Opinions recommendation of Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2015
T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease
Nature Structural & Molecular Biology·2014· 192 cited
Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes
Diabetes·2013· 186 citedOpen Access
Faculty Opinions recommendation of Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2013
Changing faces, unmasking the beta-cell
Current Opinion in Endocrinology Diabetes and Obesity·2013· 22 cited
Faculty Opinions recommendation of Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2012
Faculty Opinions recommendation of A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2012Open Access
Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire
Journal of Biological Chemistry·2011· 74 citedOpen Access
PS13 - 66. The type 1 diabetes associated HLA-DQ8-transdimer accommodates a unique islet peptide repertoire
Nederlands Tijdschrift voor Diabetologie·2011
Gluten-Specific T Cells Cross-React between HLA-DQ8 and the HLA-DQ2α/DQ8β Transdimer
The Journal of Immunology·2011· 55 cited
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Frequent Co-authors

Bart O. Roep(19), Peter A. van Veelen(9), Arnaud Zaldumbide(8), Philip G. de Groot(8), Jan W. Drijfhout(8), Marcel Verheij(7), Ronald H. W. M. Derksen(6), Maarten Pennings(6), Wim J. van Blitterswijk(6), Frits Koning(5), George K. Papadopoulos(5), Arnoud H. de Ru(5), Tatjana Nikolić(4), Sandra Laban(4), Rolf T. Urbanus(4), George M. C. Janssen(4), Antonis K. Moustakas(4), Jeffrey Klarenbeek(4), Antoinette M. Joosten(3), Bas de Laat(3)