Jens Hjerling‐Leffler

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index24.6kcitations161works8.22yr avg
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Research Topics

Single-cell and spatial transcriptomics(34), Genetic Associations and Epidemiology(32), CRISPR and Genetic Engineering(31), RNA regulation and disease(30), RNA and protein synthesis mechanisms(29)

Publications155 total

A novel key player in cognitive striatal processes: the Pthlh interneurons
2025
Integrating multi-omic summary data identifies candidate molecular mechanisms for Major Depression
Biological Psychiatry·2025Open Access
Cell Type Specific Inference of Perturbations in Synaptic Communication with MultiNeuronChat
2025Open Access
Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes
Nature Communications·2025· 1 citedOpen Access
Genomic analyses reveal new insights into Alzheimer’s disease
2025· 3 cited
The Psychiatric Genomics Consortium: Discoveries and Directions
2025Open Access
The Psychiatric Genomics Consortium: Discoveries and Directions
2025· 1 citedOpen Access
The Psychiatric Genomics Consortium: discoveries and directions
The Lancet Psychiatry·2025· 12 citedOpen Access
Benchmarking methods integrating GWAS and single-cell transcriptomic data for mapping trait-cell type associations
2025· 4 citedOpen Access
Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia
2025· 5 citedOpen Access
2060 Interhemispheric Axonal Sprouting Occurs After Pial Removal in Mice, a First Step in the Development of a Cortico-Cortico Transpial Bypass
Neurosurgery·2025
Identifying patterns differing between high-dimensional datasets with generalized contrastive PCA
PLoS Computational Biology·2025· 5 citedOpen Access
The Psychiatric Genomics Consortium: Discoveries and Directions
2025Open Access
The Psychiatric Genomics Consortium: Discoveries and Directions
2025Open Access
Schizophrenia genomics: genetic complexity and functional insights
UNC Libraries·2025· 1 citedOpen Access
Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity
Nature Communications·2025· 24 citedOpen Access
Benchmarking of Single Nuclei Rna-Seq Methods on Human Post-Mortem Brain Tissue
SSRN Electronic Journal·2025Open Access
Ernest Arenas (1962–2024)
Nature Neuroscience·2024Open Access
Interhemispheric axonal sprouting occurs after pial removal in mice
Scientific Reports·2024· 2 citedOpen Access
FUNCTIONAL GENOMIC APPROACHES WITH SINGLE-CELL RESOLUTION PROVIDE MECHANISTIC AND BIOLOGICAL INSIGHTS BASED ON GENETIC ASSOCIATION STUDIES
European Neuropsychopharmacology·2024
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Frequent Co-authors

Ana B. Muñoz‐Manchado(14), Patrick F. Sullivan(14), Nathan Skene(13), Sten Linnarsson(12), Patrik Ernfors(12), Julien Bryois(11), Gord Fishell(8), Jeanne E. Savage(7), Daniëlle Posthuma(7), Sven Stringer(6), Christiaan de Leeuw(6), Peter Lönnerberg(5), Kyoko Watanabe(5), Philip R. Jansen(5), Carolina Bengtsson Gonzales(5), Amit Zeisel(4), Hermany Munguba(4), Gonçalo Castelo‐Branco(4), Kenneth D. Harris(4), Ernest Arenas(4)