Matjaž Brvar

Leibniz University Hannover — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index769citations23works7.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(13), Bioactive Compounds and Antitumor Agents(8), Synthesis and biological activity(6), Receptor Mechanisms and Signaling(5), Antibiotic Resistance in Bacteria(3)

Publications23 total

An updated patent review of MALT1 inhibitors (2021–present)
Expert Opinion on Therapeutic Patents·2025· 7 cited
CCDC 1905506: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
CCDC 1905507: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Structure–Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators
Journal of Medicinal Chemistry·2020· 9 citedOpen Access
Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1
ACS Pharmacology & Translational Science·2019· 4 citedOpen Access
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Scientific Reports·2018· 22 citedOpen Access
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Molecular Metabolism·2017· 60 citedOpen Access
Design, Synthesis, and Evaluation of Novel Tyrosine‐Based DNA Gyrase B Inhibitors
Archiv der Pharmazie·2017· 11 citedOpen Access
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors
European Journal of Medicinal Chemistry·2017· 59 citedOpen Access
3‐substituted‐1 <i>H</i> ‐indazoles as Catalytic Inhibitors of the Human DNA Topoisomerase IIα
ChemistrySelect·2017· 10 cited
Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)
Journal of Biological Chemistry·2016· 13 citedOpen Access
Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B
European Journal of Medicinal Chemistry·2016· 15 citedOpen Access
New N -phenyl-4,5-dibromopyrrolamides and N -Phenylindolamides as ATPase inhibitors of DNA gyrase
European Journal of Medicinal Chemistry·2016· 33 citedOpen Access
<i>N</i>-Phenyl-4,5-dibromopyrrolamides and <i>N</i>-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation
Journal of Medicinal Chemistry·2015· 58 cited
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-<i>d</i>]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site
Journal of Medicinal Chemistry·2015· 108 citedOpen Access
GYRASE B IN COMPLEX WITH 4,5-DIBROMOPYRROLAMIDE-BASED INHIBITOR
2015
Discovery of Mono‐ and Disubstituted 1<i>H</i>‐Pyrazolo[3,4]pyrimidines and 9<i>H</i>‐Purines as Catalytic Inhibitors of Human DNA Topoisomerase IIα
ChemMedChem·2014· 35 cited
Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIα
Bioorganic & Medicinal Chemistry Letters·2014· 28 citedOpen Access
Discovery of the first inhibitors of bacterial enzyme d-aspartate ligase from Enterococcus faecium (Aslfm)
European Journal of Medicinal Chemistry·2013· 21 cited
Structure-Based Discovery of Substituted 4,5′-Bithiazoles as Novel DNA Gyrase Inhibitors
Journal of Medicinal Chemistry·2012· 177 cited
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Frequent Co-authors

Tom Šolmajer(9), Andrej Perdih(8), Janez Ilaš(7), D. Kikelj(7), Päivi Tammela(6), Tihomir Tomašič(5), Sofía Montalvão(5), Lucíja Peterlin Mašič(5), Elisabeth Rexen Ulven(5), Trond Ulven(5), Thomas M. Frimurer(4), M. Renko(3), Nace Zidar(3), Helena Macut(3), Barbara Pogorelčnik(3), Tezz Quon(3), Eugenia Sergeev(3), Natasja Barki(3), Brian D. Hudson(3), Palash Dutta(3)