Eugenia Sergeev

Heptares Therapeutics (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index406citations17works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(12), Neuropeptides and Animal Physiology(4), Diabetes Treatment and Management(3), Crystallization and Solubility Studies(3), X-ray Diffraction in Crystallography(3)

Publications17 total

A novel somatostatin receptor ligand for human ACTH – and GH –secreting pituitary adenomas
European Journal of Endocrinology·2023· 5 citedOpen Access
Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?
Frontiers in Pharmacology·2022· 31 citedOpen Access
Effect of HTL0045725, a selective agonist of the orphan receptor GPR52, on kinase and transcription factor phosphorylation in striatal neurons
Neuroscience Applied·2022· 2 citedOpen Access
Structure‐Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2
ChemMedChem·2021· 5 citedOpen Access
Understanding Exposure-Receptor Occupancy Relationships for Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators across a Range of Preclinical and Clinical Studies
Journal of Pharmacology and Experimental Therapeutics·2021· 7 citedOpen Access
CCDC 1905506: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
CCDC 1905507: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Structure–Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators
Journal of Medicinal Chemistry·2020· 9 citedOpen Access
Chemogenetics defines receptor-mediated functions of short chain free fatty acids
Nature Chemical Biology·2019· 70 citedOpen Access
Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Journal of Medicinal Chemistry·2018· 40 citedOpen Access
CCDC 1844850: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Investigating the molecular pharmacology of the short chain fatty acid receptor FFA2
2018
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias
Scientific Reports·2017· 29 citedOpen Access
Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)
Journal of Medicinal Chemistry·2017· 33 citedOpen Access
A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias
Journal of Biological Chemistry·2016· 87 citedOpen Access
Ligands at the Free Fatty Acid Receptors 2/3 (GPR43/GPR41)
Handbook of experimental pharmacology·2016· 31 cited
Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands
Journal of Biological Chemistry·2015· 57 citedOpen Access

Frequent Co-authors

Graeme Milligan(12), Anders Højgaard Hansen(9), Trond Ulven(9), Brian D. Hudson(8), Daniele Bolognini(6), Elisabeth Rexen Ulven(6), Andrew B. Tobin(5), Christine J. McKenzie(5), Natasja Barki(4), K.A. Bennett(4), Geor Bakker(3), Tezz Quon(3), Matjaž Brvar(3), Palash Dutta(3), Sophie J. Bradley(2), Richard R. Sprenger(2), Jeppe H. Ekberg(2), Christer S. Ejsing(2), Sunil K. Pandey(2), Cliona MacSweeney(2)