Philip D. Mosier

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index3.1kcitations67works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Receptor Mechanisms and Signaling(26), Neuropeptides and Animal Physiology(18), Pharmacological Receptor Mechanisms and Effects(16), Proteoglycans and glycosaminoglycans research(10), Neurotransmitter Receptor Influence on Behavior(8)

Publications67 total

Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect
European Journal of Medicinal Chemistry·2021· 4 citedOpen Access
Differential Helical Orientations among Related G Protein-coupled Receptors Provide a Novel Mechanism for Selectivity: STUDIES WITH SALVINORIN A AND THE κ-OPIOID RECEPTOR
UNC Libraries·2021Open Access
Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists
UNC Libraries·2020Open Access
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior
UNC Libraries·2020· 1 citedOpen Access
CoMFA analyses of C-2 position Salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity
UNC Libraries·2020Open Access
Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT 2A Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling Investigation
Figshare·2020Open Access
Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor
Carolina Digital Repository (University of North Carolina at Chapel Hill)·2020Open Access
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides
UNC Libraries·2020Open Access
9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites
UNC Libraries·2020Open Access
Synthesis, structure–affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: Structural factors contributing to selectivity
UNC Libraries·2020Open Access
Structure-Based Design, Synthesis, and Biochemical and Pharmacological Characterization of Novel Salvinorin A Analogues as Active State Probes of the κ-Opioid Receptor
UNC Libraries·2020Open Access
Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT2A receptor
UNC Libraries·2020Open Access
Discovering novel anticancer allosteric inhibitors of HER2 homodimerization
2020
Discovering novel anticancer allosteric inhibitors of HER2 homodimerization
2020
High-Affinity Sigma-1 (σ <sub>1</sub> ) Receptor Ligands Based on the σ <sub>1</sub> Antagonist PB212
Future Medicinal Chemistry·2019· 6 cited
“Methylene Bridge” to 5-HT<sub>3</sub> Receptor Antagonists: Conformationally Constrained Phenylguanidines
ACS Chemical Neuroscience·2018· 4 cited
Discovery and Biochemical Characterization of PlyP56, PlyN74, and PlyTB40—Bacillus Specific Endolysins
Viruses·2018· 29 citedOpen Access
Complete Genome Sequences of Bacillus Phages Janet and OTooleKemple52
Genome Announcements·2018· 1 citedOpen Access
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Cell·2018· 362 citedOpen Access
Crystal structure of Influenza A virus Matrix Protein M1(NLS-88R)
2017
page 1 of 4Next →

Frequent Co-authors

Bryan L. Roth(16), Umesh R. Desai(16), Richard B. Westkaemper(12), Eyal Vardy(6), Qibing Zhou(5), Hang Xie(5), Vsevolod Katritch(4), Raymond C. Stevens(4), Arjun Raghuraman(4), Glen E. Kellogg(4), Carmen Abate(4), Richard A. Glennon(4), Martin K. Safo(4), Faik N. Musayev(4), Xi‐Ping Huang(3), Saheem A. Zaidi(3), Jordan K. Zjawiony(3), Peter C. Jurs(3), Nehru Viji Sankaranarayanan(3), Mauro Niso(3)