Janel Huffman

Ionis Pharmaceuticals (United States) — United States

Medicine · Health Sciences

8h-index413citations16works0.02yr avg
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Research Topics

CAR-T cell therapy research(13), Immune Cell Function and Interaction(8), CRISPR and Genetic Engineering(5), Multiple Myeloma Research and Treatments(3), Asthma and respiratory diseases(2)

Publications16 total

Systemic and Local Delivery of siRNA to the CNS and Periphery via Anti-IGF1R Antibody Conjugation
2026Open Access
Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma
Nature Communications·2022· 71 citedOpen Access
Dual antigen–targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia
Blood·2022· 79 citedOpen Access
Abstract 1138: Detection of genetically engineered iPSC-derived natural killer cells in blood and tissue
Cancer Research·2022
DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma
Proceedings of the National Academy of Sciences·2022· 31 citedOpen Access
Off-the-Shelf, Multiplexed-Engineered iPSC-Derived NK Cells Mediate Potent Multi-Antigen Targeting of B-Cell Malignancies with Reduced Cytotoxicity Against Healthy B Cells
Blood·2021· 9 cited
117 FT536 Path to IND: Ubiquitous targeting of solid tumors with an off-the-shelf, first-of-kind MICA/B-specific CAR-iNK cellular immunotherapy
Regular and Young Investigator Award Abstracts·2021· 3 citedOpen Access
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
Cell stem cell·2021· 147 citedOpen Access
Abstract 1591: FT536: Preclinical development of a novel off-the-shelf CAR-MICA/B NK cell immunotherapy combined with radiation and antibody treatments as a first-of-kind pan-cancer targeting strategy
Cancer Research·2021· 8 cited
A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma
European Respiratory Journal·2021· 17 citedOpen Access
Development of a Novel MICA/B-Specific CAR As a Pan-Tumor Targeting Strategy for Off-the-Shelf, Cell-Based Cancer Immunotherapy
Blood·2020· 2 cited
114 Preclinical development of a novel iPSC-derived CAR-MICA/B NK cell immunotherapy to overcome solid tumor escape from NKG2D-mediated mechanisms of recognition and killing
Regular and Young Investigator Award Abstracts·2020· 1 citedOpen Access
FT538: Preclinical Development of an Off-the-Shelf Adoptive NK Cell Immunotherapy with Targeted Disruption of CD38 to Prevent Anti-CD38 Antibody-Mediated Fratricide and Enhance ADCC in Multiple Myeloma When Combined with Daratumumab
Blood·2019· 16 cited
FT576: A Novel Multiplexed Engineered Off-the-Shelf Natural Killer Cell Immunotherapy for the Dual-Targeting of CD38 and Bcma for the Treatment of Multiple Myeloma
Blood·2019· 29 cited
Abstract LB-073: Generation of novel single cell-derived engineered master pluripotent cell line as a renewable source for off-the-shelf TCR-less CAR T cells in support of first-of-kind clinical trial
Cancer Research·2019
Abstract LB-073: Generation of novel single cell-derived engineered master pluripotent cell line as a renewable source for off-the-shelf TCR-less CAR T cells in support of first-of-kind clinical trial
Immunology·2019

Frequent Co-authors

Bahram Valamehr(13), Ryan Bjordahl(11), Svetlana Gaidarova(9), Ramzey Abujarour(9), Greg Bonello(8), Mochtar Pribadi(8), Thomas Dailey(7), Sajid Mahmood(6), Tom Lee(6), John Goulding(5), Jeffrey S. Miller(5), Frank Cichocki(5), Hui-Yi Chu(5), Lauren Fong(5), Zachary Davis(4), Hongbo Wang(4), Katie Tuininga(4), Moyar Ge(4), Tom T. Lee(4), Brian Groff(4)