Paul E. Brennan

Discovery Centre — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

59h-index15.3kcitations524works2.52yr avg
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Research Topics

Protein Degradation and Inhibitors(111), Multiple Myeloma Research and Treatments(54), Histone Deacetylase Inhibitors Research(54), Epigenetics and DNA Methylation(38), Glycosylation and Glycoproteins Research(35)

Publications515 total

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells
Nature Communications·2025· 2 citedOpen Access
Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis
JNCI Journal of the National Cancer Institute·2025Open Access
Antifungal, antibacterial, and anti-inflammatory activity of glycerol dithionomonolaurate, an analog of glycerol monolaurate
mSphere·2025Open Access
Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses
International Journal of Cancer·2025Open Access
MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens
Cell Reports Methods·2025Open Access
Transfer Learning for Heterocycle Retrosynthesis
Journal of Chemical Information and Modeling·2025· 1 citedOpen Access
Inhibition of MLLT1 limits growth of MLL-AF4 leukaemias without killing healthy haematopoietic stem cells
2025Open Access
Abstract 3815: High-penetrance rare variants underlying familial lung cancer risk: Insights from the Genetic Epidemiology of Lung Cancer Consortium
Cancer Research·2025
A patent review of peptidylarginine deiminase 4 (PAD4) inhibitors (2014–present)
Expert Opinion on Therapeutic Patents·2025· 10 cited
CAPN2: A Target Enabling Package
Zenodo (CERN European Organization for Nuclear Research)·2025Open Access
Drug repurposing in amyotrophic lateral sclerosis (ALS)
Expert Opinion on Drug Discovery·2025· 4 citedOpen Access
Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Journal of Proteome Research·2025· 7 citedOpen Access
A Live Cell BRET Probe to Quantify PRMT5-MTA Uncompetitive Target Engagement
2025Open Access
Identification and characterization of human <i>KALRN</i> mRNA and Kalirin protein isoforms
Cerebral Cortex·2024· 1 citedOpen Access
The Emory‐Sage‐SGC‐JAX TREAT‐AD Center: Target Enabling Packages for Alzheimer’s Disease Emerging Targets
Alzheimer s & Dementia·2024Open Access
MITOCHONDRIAL DYSFUNCTION IN NEUROSCIENCE: RECENT DEVELOPMENTS IN USP30 INHIBITORS
Medicinal chemistry reviews·2024
The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research
Nucleic Acids Research·2024· 9 citedOpen Access
Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer
Biomolecules·2024· 3 citedOpen Access
Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex
Journal of Medicinal Chemistry·2024Open Access
The benefits of translating biomedical research at drug discovery institutes
Nature Reviews Drug Discovery·2024
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Frequent Co-authors

Stefan Knapp(22), Susanne Müller(21), P. Filippakopoulos(12), S. Picaud(11), Octovia Monteiro(11), O. Fedorov(10), Anthony Tumber(10), Martin Philpott(9), Oleg Fedorov(9), Catherine Rogers(9), Christopher J. Schofield(9), Christopher Wells(8), Sarah Martin(8), C. Tallant(8), C. Bountra(7), Brian D. Marsden(7), Mark E. Bunnage(6), Dafydd R. Owen(6), James M. Bennett(6), F. von Delft(6)