Mark K. Saville

University of Dundee — United Kingdom

Medicine · Health Sciences

26h-index3.9kcitations35works0.02yr avg
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Research Topics

Cancer-related Molecular Pathways(21), Ubiquitin and proteasome pathways(17), Epigenetics and DNA Methylation(6), Cancer-related gene regulation(4), Genomics and Chromatin Dynamics(3)

Publications35 total

Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor <scp>MDM2</scp>
FEBS Letters·2022Open Access
Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6
Oncogene·2022· 52 citedOpen Access
The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma
Journal of Investigative Dermatology·2019· 16 citedOpen Access
Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity
Oncotarget·2018· 19 citedOpen Access
Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity
Oncotarget·2018· 26 citedOpen Access
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a
Oncogene·2013· 45 citedOpen Access
p53 is activated in response to disruption of the pre-mRNA splicing machinery
Oncogene·2012· 90 cited
Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation
Respiratory Research·2010Open Access
Targeting the ubiquitin–proteasome system to activate wild-type p53 for cancer therapy
Seminars in Cancer Biology·2009· 51 cited
MdmX is a substrate for the deubiquitinating enzyme USP2a
Oncogene·2009· 96 cited
Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53
Journal of Biological Chemistry·2008· 200 citedOpen Access
Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma
Journal of Biological Chemistry·2008· 81 citedOpen Access
Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-κB- and p53-regulated gene targets
Cell Death and Differentiation·2007· 44 citedOpen Access
Clinical aspects of coagulation
Anaesthesia & intensive care medicine·2007· 4 cited
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
The EMBO Journal·2007· 276 citedOpen Access
Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
Oncogene·2007· 25 citedOpen Access
Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules
The EMBO Journal·2006· 271 citedOpen Access
p53 isoforms can regulate p53 transcriptional activity
Genes & Development·2005· 792 citedOpen Access
p14 Arf Promotes Small Ubiquitin-like Modifier Conjugation of Werners Helicase
Journal of Biological Chemistry·2004· 61 citedOpen Access
Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo
Journal of Biological Chemistry·2004· 156 citedOpen Access
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Frequent Co-authors

David P. Lane(11), Alison Sparks(9), Dimitris P. Xirodimas(7), Nerea Allende-Vega(6), Jean‐Christophe Bourdon(4), Kenneth Fernandes(4), Saurabh Dayal(3), Roger J. Watson(3), Maria João Bessa(3), Miles D. Houslay(3), Angela McHugh(3), Charlotte M. Proby(3), Irene M. Leigh(3), Ronald T. Hay(2), Lauren Stevenson(2), Carol Midgley(2), Yvonne L. Woods(2), David W. Meek(2), R J Watson(2), Manel Joaquin(2)