Tetsuya Akiyama

Tohoku University — Japan

Medicine · Health Sciences

21h-index2.7kcitations51works5.52yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(29), Neurogenetic and Muscular Disorders Research(21), RNA Research and Splicing(10), Muscle Physiology and Disorders(4), Nerve injury and regeneration(4)

Publications46 total

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes
Nature Neuroscience·2025· 11 citedOpen Access
ALS-associated RNA-binding proteins promote UNC13A transcription through REST downregulation
The EMBO Journal·2025Open Access
KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS
2025Open Access
Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 loss
2025· 5 citedOpen Access
Updated Genetic Analysis of Japanese Familial ALS Patients Carrying <i>SOD1</i> Variants Revealed Phenotypic Differences for Common Variants
Neurology Genetics·2024· 4 citedOpen Access
ALS-associated RNA binding proteins converge on <i>UNC13A</i> transcription through regulation of REST
2024Open Access
Electroproduction of the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="normal">Λ</mml:mi><mml:mtext>/</mml:mtext><mml:msup><mml:mi mathvariant="normal">Σ</mml:mi><mml:mn>0</mml:mn></mml:msup></mml:math> hyperons at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mi>Q</mml:mi><mml:mn>2</mml:mn></mml:msup><mml:mo>≃</mml:mo><mml:mn>0.5</mml:mn></mml:mrow></mml:math> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow><mml:mo>(</mml:mo><mml:mi>GeV</mml:mi><mml:mo>/</mml:mo><mml:mi>c</mml:mi><mml:mo>)</mml:mo></mml:mrow><mml:mn>2</mml:mn></mml:msup></mml:math> at forward angles
Physical review. C·2024· 1 citedOpen Access
TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes
2024· 23 citedOpen Access
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
Cell Reports·2022· 13 citedOpen Access
Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2
Cell Reports·2022· 24 citedOpen Access
Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers
Clinical and Translational Medicine·2022· 27 citedOpen Access
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
Nature·2022· 524 citedOpen Access
Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
2021· 1 citedOpen Access
Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2
2021Open Access
Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations
Stem Cell Reports·2021· 25 citedOpen Access
Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN
Neurobiology of Disease·2021· 22 citedOpen Access
Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN
2021
An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3
iScience·2020· 32 citedOpen Access
Generation of an ALS human iPSC line KEIOi001-A from peripheral blood of a Charcot disease-affected patient carrying TARDBP p.N345K heterozygous SNP mutation
Stem Cell Research·2020· 8 citedOpen Access
Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)
Frontiers in Neuroscience·2020· 44 citedOpen Access
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Frequent Co-authors

Masashi Aoki(30), Naoki Suzuki(24), Hitoshi Warita(24), Ayumi Nishiyama(14), Rumiko Izumi(14), Hideyuki Okano(11), Aaron D. Gitler(10), Shio Mitsuzawa(10), Mitsuru Ishikawa(8), Kensuke Ikeda(8), Hiroya Ono(8), Tomomi Shijo(8), Masaaki Kato(8), Takefumi Sone(7), Keiko Nakayama(7), Shion Osana(6), Yasuo Kitajima(6), Garam Kım(5), Caitlin M. Rodriguez(5), Leonard Petrucelli(5)