Nicole Borth

Austrian Centre of Industrial Biotechnology (Austria) — Austria

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index6.9kcitations224works2.12yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(144), CRISPR and Genetic Engineering(67), Virus-based gene therapy research(36), Microbial Metabolic Engineering and Bioproduction(29), Protein purification and stability(24)

Publications222 total

Nanopore Cas9‐targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells
Biotechnology and Bioengineering·2023· 14 citedOpen Access
Single-cell RNA sequencing reveals homogeneous transcriptome patterns and low variance in a suspension CHO-K1 and an adherent HEK293FT cell line in culture conditions
Journal of Biotechnology·2023· 18 citedOpen Access
SLAM‐seq reveals early transcriptomic response mechanisms upon glutamine deprivation in Chinese hamster ovary cells
Biotechnology and Bioengineering·2022· 7 cited
Nanopore Cas9-targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells
2022· 1 cited
Nanopore Cas9-targeted sequencing enables accurate and simultaneous identification of transgene integration sites, their structure and epigenetic status in recombinant Chinese hamster ovary cells
2022· 1 citedOpen Access
Never let me down: new possibilities for lowering serum free cultivation media costs
2022· 5 citedOpen Access
In silico design of CMV promoter binding oligonucleotides and their impact on inhibition of gene expression in Chinese hamster ovary cells
Journal of Biotechnology·2022· 3 citedOpen Access
Codon and signal peptide optimization for therapeutic antibody production from Chinese hamster ovary (CHO) cell
Biochemical and Biophysical Research Communications·2022· 13 cited
Nafamostat is a Potent Human Diamine Oxidase Inhibitor Possibly Augmenting Hypersensitivity Reactions during Nafamostat Administration
Journal of Pharmacology and Experimental Therapeutics·2022· 3 citedOpen Access
Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine
Inflammation Research·2022· 10 citedOpen Access
How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines
Biotechnology Advances·2022· 28 citedOpen Access
Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation
2022· 4 citedOpen Access
Flexible Nets to optimize antibody production in chinese hamster ovary cells
Faculty of 1000 Research Ltd·2022Open Access
Glycosylation site Asn168 is important for slow in vivo clearance of recombinant human diamine oxidase heparin-binding motif mutants
Glycobiology·2021· 3 cited
Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical
eLife·2021· 13 citedOpen Access
Author response: Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical
2021Open Access
A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells
Biotechnology Reports·2021· 11 citedOpen Access
Inclusion of maintenance energy improves the intracellular flux predictions of CHO
PLoS Computational Biology·2021· 11 citedOpen Access
Towards rational glyco-engineering in CHO: from data to predictive models
Current Opinion in Biotechnology·2021Open Access
Enhanced targeted DNA methylation of the CMV and endogenous promoters with dCas9-DNMT3A3L entails distinct subsequent histone modification changes in CHO cells
Metabolic Engineering·2021· 30 citedOpen Access
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Frequent Co-authors

Matthias Hackl(12), Vaibhav Jadhav(12), Johannes Grillari(11), Martina Baumann(10), Renate Kunert(8), Michael Hanscho(7), Karina Brinkrolf(7), Diethard Mattanovich(6), Hermann Katinger(6), Oliver Rupp(6), Alexander Goesmann(6), Alfred Pühler(6), Juan A. Hernández Bort(6), Michael J. Betenbaugh(5), Thomas Noll(5), Jürgen Zanghellini(4), Lars K. Nielsen(4), Nathan E. Lewis(4), Norbert Auer(4), Daniela Huber(4)