Domenico Cozzetto

British Heart Foundation — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index6.6kcitations103works1.52yr avg
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Research Topics

Inflammatory Bowel Disease(28), Protein Structure and Dynamics(19), Microscopic Colitis(19), Machine Learning in Bioinformatics(17), Cancer Immunotherapy and Biomarkers(15)

Publications103 total

Redox-activated induction of Warburg-type metabolism in the adult heart
2026Open Access
P0198 The magnitude of enrichment of functionally distinct transcriptional modules defines a novel molecular classification of Ulcerative Colitis that differentiates patient trajectories
Journal of Crohn s and Colitis·2026Open Access
DOP076 Spatially and functionally uncoupled cytokine responses differentially activate wound healing and keratinisation responses in a prognostically relevant manner in perianal fistulising Crohn’s disease
Journal of Crohn s and Colitis·2026
P0179 IL-22-driven inflammatory and drug resistance pathways are JAK1-dependent in a human 3D mini-gut organoid system
Journal of Crohn s and Colitis·2026
OP27 Integrative single-cell, spatial, and clinical analysis supports JAK1 inhibition as a compelling therapeutic strategy in perianal Crohn’s disease
Journal of Crohn s and Colitis·2026
P0084 The IL-27/IFNg/JAK1 axis is functionally important in immune checkpoint inhibitor- induced colitis
Journal of Crohn s and Colitis·2026
OP09 Polyfunctional cytotoxic CD4+ T cells associate with mucosal inflammation and predict treatment resistance in Ulcerative Colitis
Journal of Crohn s and Colitis·2026
Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD
Molecular Systems Biology·2025Open Access
P0121 Molecular features of extracellular matrix activity persist in patients who achieve mucosal healing with ustekinumab induction
Journal of Crohn s and Colitis·2025Open Access
DOP122 Unravelling the molecular landscape of anti-TNF failure in Ulcerative Colitis identifies MEK/ERK inhibitors as putative therapeutic candidates
Journal of Crohn s and Colitis·2025Open Access
DOP067 Selective JAK1 blockade with Upadacitinib is effective in immune checkpoint inhibitor-induced colitis
Journal of Crohn s and Colitis·2025· 1 citedOpen Access
P0128 IL-27 signalling, but not IL-1B, is functionally relevant in the pathophysiology of immune checkpoint inhibitor induced colitis
Journal of Crohn s and Colitis·2025Open Access
P0118 A novel subset of TNIP3+ OLR1+ AQP9+ inflammatory monocytes drives resistance to multiple biologics in ulcerative colitis
Journal of Crohn s and Colitis·2025Open Access
CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner
Nature Communications·2024· 11 citedOpen Access
Solid tumor immunotherapy using NKG2D-based adaptor CAR T cells
Cell Reports Medicine·2024· 16 citedOpen Access
Decoding Non-coding SNPs: Systems Genomics Modelling Dissects the Heterogeneity of IBD
2024Open Access
O29 A core transcriptional resistome, characterised by neutrophil degranulation and extracellular matrix dysregulation, predicts resistance to multiple therapies in UC
Oral Presentations·2024
Tu1761 GENE CORRELATION NETWORK ANALYSES REVEAL TRANSCRIPT MODULES AND PATHOGENIC MECHANISMS ASSOCIATED WITH RESISTANCE AND RESPONSE TO USTEKINUMAB THERAPY IN ULCERATIVE COLITIS
Gastroenterology·2024
Tu1734 BLOCKADE OF IL-27, BUT NOT IL-1B, ATTENUATES IMMUNE CHECKPOINT INHIBITOR COLITIS
Gastroenterology·2024
Tu1762 A CORE TRANSCRIPTIONAL RESISTOME, CHARACTERISED BY NEUTROPHIL DEGRANULATION AND EXTRACELLULAR MATRIX DYSREGULATION, PREDICTS RESISTANCE TO MULTIPLE THERAPIES IN UC
Gastroenterology·2024
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Frequent Co-authors

David T. Jones(18), Nick Powell(12), Anna Tramontano(12), Tamás Korcsmáros(8), Cen Wan(6), Rui Fa(6), Graham M. Lord(6), Jianlin Cheng(5), Julian Gough(5), Jonathan W. Lo(5), Mansoor Saqi(5), Matthew Madgwick(5), Rita Casadio(4), Hai Fang(4), Petri Törönen(4), Liisa Holm(4), Daniel Buchan(4), Kevin Bryson(4), Haixuan Yang(4), Alfonso E. Romero(4)