Thomas A. Krenitsky

Boston University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index6.0kcitations109works0.02yr avg
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Research Topics

Biochemical and Molecular Research(49), Herpesvirus Infections and Treatments(23), Cytomegalovirus and herpesvirus research(20), Adenosine and Purinergic Signaling(20), HIV/AIDS drug development and treatment(18)

Publications109 total

Phase I Study of 506U78 Administered on a Consecutive 5-Day Schedule in Children and Adults With Refractory Hematologic Malignancies
Journal of Clinical Oncology·2005· 174 citedOpen Access
KP544 amplifies the effects of nerve growth factor on cell differentiation and is neuroprotective
Drug Development Research·2004· 3 cited
KP544, a nerve growth factor amplifier: Pharmacokinetics, safety, and efficacy in the rat
Drug Development Research·2004· 5 cited
Guest Editorial
Nucleosides Nucleotides & Nucleic Acids·2000
Tributes to <i>Gertrude Elion</i>
The Oncologist·1999Open Access
The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology
Structure·1997· 126 citedOpen Access
1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity
Antimicrobial Agents and Chemotherapy·1997· 384 citedOpen Access
Metabolism and pharmacokinetics of a double prodrug of ganciclovir in the rat and monkey.
Drug Metabolism and Disposition·1995· 10 cited
2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies.
PubMed·1995· 96 cited
Anti-HIV agent 935U83 — Preliminary clinical assessment
Antiviral Research·1995· 4 cited
Novel Carbohydrate Conjugates as Potential Prodrugs of Acyclovir
Antiviral chemistry & chemotherapy·1994· 8 cited
ChemInform Abstract: Novel 6‐Alkoxypurine 2′,3′‐Dideoxynucleosides, e.g. (I), as Inhibitors of the Cytopathic Effect of the Human Immunodeficiency Virus.
ChemInform·1994· 2 cited
Varicella-Zoster virus thymidine kinase
Biochemical Pharmacology·1993· 15 cited
Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus
Journal of Medicinal Chemistry·1993· 28 cited
Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents
Journal of Medicinal Chemistry·1993· 62 cited
Review of research leading to new anti-herpesvirus agents in clinical development: Valaciclovir hydrochloride (256u, the L-valyl ester of acyclovir) and 882c, a specific agent for varicella zoster virus
Journal of Medical Virology·1993· 50 cited
6-Dimethylamino-9-(β-d-arabinofuranosyl)-9H-purine: Pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys
Antiviral Research·1993· 2 cited
Acyclovir prodrugs: The road to valaciclovir
Drugs of the Future·1993· 37 cited
2-Ester Prodrugs of the Varicella-Zoster Antiviral Agent, 6-Methoxypurine Arabinoside
Antiviral chemistry & chemotherapy·1992· 9 cited
A novel human phosphotransferase highly specific for adenosine
Archives of Biochemistry and Biophysics·1992· 11 cited
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Frequent Co-authors

Gertrude B. Elion(12), George W. Koszalka(12), Joel V. Tuttle(9), Janet L. Rideout(6), Richard L. Miller(6), Lilia M. Beauchamp(5), Wayne H. Miller(4), George H. Hitchings(4), Esther Y. Chao(4), Willard W. Hall(4), D R Averett(3), P de Miranda(3), L M Beacham(3), Donald J. Nelson(3), Randolph L. Berens(3), J. Joseph Marr(3), Thomas Spector(3), S.E. Ealick(3), Naomi K. Cohn(3), M H St Clair(2)