Burcu Bestas

Karolinska Institutet — Sweden

Immunology and Microbiology · Life Sciences

13h-index673citations26works0.32yr avg
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Research Topics

Immunodeficiency and Autoimmune Disorders(9), Chronic Lymphocytic Leukemia Research(7), Advanced biosensing and bioanalysis techniques(6), RNA Interference and Gene Delivery(6), CRISPR and Genetic Engineering(6)

Publications26 total

Author response for "Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in <i>BTK</i>/<i>Tec</i> double deficient X-linked agammaglobulinemia model"
2025
Author response for "Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in <i>BTK</i>/<i>Tec</i> double deficient X-linked agammaglobulinemia model"
2025
Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in <i>BTK</i> / <i>Tec</i> double deficient X-linked agammaglobulinemia model
RSC Chemical Biology·2025· 1 citedOpen Access
A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo
Nature Communications·2023· 18 citedOpen Access
Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
Nature Communications·2023· 108 citedOpen Access
Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
2022· 6 citedOpen Access
Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
Nature Communications·2022· 48 citedOpen Access
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Biomedicines·2021· 17 citedOpen Access
Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
2021· 3 citedOpen Access
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes
Molecular Therapy·2021· 25 citedOpen Access
The viral protein corona directs viral pathogenesis and amyloid aggregation
Nature Communications·2019· 213 citedOpen Access
The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation
2018· 20 citedOpen Access
581. Correcting Exon Skipping Splicing Defects in BTK RNA by Using Bifunctional Oligonucleotides
Molecular Therapy·2016Open Access
Synthetic m<sub>3</sub>G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal
RSC Advances·2016· 8 citedOpen Access
Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency
Molecular Therapy — Nucleic Acids·2016· 21 citedOpen Access
Design and application of RNA therapeutics for splice site mutations
Figshare·2015Open Access
695. Splice-Correction of X-Linked Agammaglobulinemia in a Human BAC-Transgenic Mouse Model Using Oligonucleotides
Molecular Therapy·2015Open Access
Splice-Correction Strategies for Treatment of X-Linked Agammaglobulinemia
Current Allergy and Asthma Reports·2015· 18 citedOpen Access
Personalized therapy for X-linked agammaglobulinemia (XLA) by oligonucleotide-induced splice-correction
Human Gene Therapy·2014
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
Journal of Clinical Investigation·2014· 47 citedOpen Access
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Frequent Co-authors

Smith Rjh(15), Samir EL Andaloussi(12), Matthew J. A. Wood(9), Jesper Wengel(9), Karin E. Lundin(8), Anna Berglöf(8), Robert Månsson(7), Mike Firth(6), Marcello Maresca(6), Pedro M. D. Moreno(6), Mohammad H. Forouzanfar(6), Sandra Wimberger(5), Songyuan Li(5), Shabnam Kharazi(5), Oscar P. B. Wiklander(5), Thomas C. Roberts(4), Nina Akrap(4), Pei-Pei Hsieh(4), Saša Šviković(4), Pınar Akçakaya(4)