Brian O’Rourke

Johns Hopkins University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

93h-index28.4kcitations449works0.42yr avg
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Research Topics

Mitochondrial Function and Pathology(162), Cardiac electrophysiology and arrhythmias(109), Cardiac Ischemia and Reperfusion(102), Ion channel regulation and function(60), ATP Synthase and ATPases Research(40)

Publications449 total

It's time to reimagine reimbursement for CAR T-cell therapy
The American Journal of Managed Care·2025
Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure
Journal of Biological Chemistry·2025Open Access
Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression
ACS Omega·2025Open Access
Proteomic Insights into Cardiometabolic Remodeling in SARS-CoV-2-Infected Hamsters
Journal of Molecular and Cellular Cardiology Plus·2025Open Access
Formate yields protection from ischemic injury through a nitric oxide synthase-dependent increase in protein S-nitrosation
Journal of Molecular and Cellular Cardiology Plus·2025Open Access
The DCT2/CNT is the Major Site of Regulated ROMK-Mediated K<sup>+</sup>Secretion
Physiology·2025
<b>Coumarins disrupt cell-cell communication for control of pathogenesis and virulence in ESKAPEEs and fungal opportunists</b>
2025Open Access
Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression
2024· 1 citedOpen Access
Abstract Tu055: Prominent effects of p38 MAPK inhibition on the phosphoproteome of a guinea pig model of heart failure and sudden cardiac death
Circulation Research·2024
Sex-dependent phosphorylation of Argonaute 2 reduces the mitochondrial translocation of miR-181c and induces cardioprotection in females
Journal of Molecular and Cellular Cardiology·2024· 1 citedOpen Access
Evolving assessment pathways for precision oncology medicines to improve patient access: a tumor-agnostic lens
The Oncologist·2024· 1 citedOpen Access
Regulation of stress granules by O-GlcNAcylation in stressed and ischemic cardiomyocytes
Biophysical Journal·2024
Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19
2024· 2 citedOpen Access
Abstract 18791: Sex Differences in the Phosphorylation of Argonaute 2 Result in Reduced Translocation of Micro RNA-181c Into the Mitochondria and Cardioprotection in Pre-Menopausal Females
Circulation·2023
Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity
Cell chemical biology·2023· 14 citedOpen Access
Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors
Journal of the American Heart Association·2023· 4 citedOpen Access
Abstract P3072: Effects Of Antiviral Innate Immune Activation On Cytokine Secretion And Function Of Human Ipsc-derived Cardiomyocytes
Circulation Research·2023
Abstract P1166: O-GlcNAcylation Regulates Protein Synthesis In Cardiomyocytes Through Effects On The Translational Regulator Eif2α
Circulation Research·2023
Abstract P3195: Mitochondrial CaMKII Drives Cardiometabolic Dysfunction In Heart Failure
Circulation Research·2023
Abstract P2189: Role Of Innate Immune Response And Mitochondrial Ros In The Cardiac And Pulmonary Sequelae Of Covid-19
Circulation Research·2023
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Frequent Co-authors

Eduardo Marbán(16), Miguel A. Aon(12), Sonia Cortassa(10), Raimond L. Winslow(5), Ting Liu(5), David A. Kass(4), Gordon F. Tomaselli(4), Christoph Maack(4), Toshiaki Sato(3), Ion A. Hobai(3), Agnieszka Sidor(3), Norihito Sasaki(3), D. Brian Foster(3), Yongge Liu(2), Stefan Kääb(2), Masaharu Akao(2), Andreas Ohler(2), Michael T. Crow(2), Jasma Rucker(2), Kenneth A. Oye(2)