Melissa Holstein

Bristol-Myers Squibb (Germany) — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index760citations37works3.02yr avg
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Research Topics

Protein purification and stability(27), Monoclonal and Polyclonal Antibodies Research(11), Viral Infectious Diseases and Gene Expression in Insects(10), Analytical Chemistry and Chromatography(6), Enzyme Structure and Function(5)

Publications37 total

A case study showing the role of hydrophobicity variants and other enriched <scp>mAb</scp> proteoforms on filterability through a virus filter with productivity improvement measures
Biotechnology Progress·2026Open Access
Impact of Eco‐Friendly Surfactant Structure and Class on Enveloped Virus Inactivation
Biotechnology Journal·2025
Understanding the Impact of Combined Hydrodynamic Shear and Interfacial Dilatational Stress, on Interface-Mediated Particle Formation for Monoclonal Antibody Formulations
Journal of Pharmaceutical Sciences·2024· 9 citedOpen Access
The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes
Biotechnology Journal·2023· 5 citedOpen Access
Strategies for UF/DF-Based Impurity Removal in the Post-conjugation Purification of Antibody–Drug Conjugates
Organic Process Research & Development·2023· 9 cited
Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer
Biotechnology Progress·2022· 1 cited
Author response for "Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer"
2022
Assessing detergent‐mediated virus inactivation, protein stability, and impurity clearance in biologics downstream processes
Biotechnology and Bioengineering·2022· 12 cited
Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes
Biotechnology Progress·2022· 17 citedOpen Access
An Ästhetik: Warum ist weniger mehr?
2022
Virus inactivation at moderately low pH varies with virus and buffer properties
Biotechnology Journal·2021· 13 cited
Assessing detergent-mediated virus inactivation, protein stability and impurity clearance in biologics downstream processes
2021Open Access
Surrogate model to screen for inactivation‐based clearance of enveloped viruses during biotherapeutics process development
Biotechnology Journal·2021· 9 cited
Affinity precipitation of monoclonal antibodies using ELP-Z in the elution without resolubilization mode
Journal of Biotechnology·2021· 3 cited
Physiochemical properties of enveloped viruses and arginine dictate inactivation
Biotechnology Journal·2021· 16 cited
Establishing a surrogate model for inactivation of enveloped viruses to screen viral clearance conditions during biotherapeutics process development
2021Open Access
Using continuous chromatography methodology to achieve high-productivity and high-purity enrichment of charge variants for analytical characterization
Journal of Chromatography A·2021· 20 cited
Process analytical technology for on‐line monitoring of quality attributes during single‐use ultrafiltration/diafiltration
Biotechnology and Bioengineering·2021· 15 cited
Antibody retention by virus filtration membranes: Polarization and sieving effects
Journal of Membrane Science·2020· 18 citedOpen Access
Control of leached <scp>beta‐glucan</scp> levels from depth filters by an improved depth filtration flush strategy
Biotechnology Progress·2020· 8 cited
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Frequent Co-authors

Sanchayita Ghose(20), Zheng Jian Li(16), Hasin Feroz(14), Steven M. Cramer(8), Jessica Hung(6), Swarnim Ranjan(6), Wai Keen Chung(5), Alexander S. Freed(5), Scott A. McCallum(4), Dongyoun Jang(4), Christine Urrea(4), Lakshmi Sirisha Botta(4), Steven M. Cramer(3), Siddharth Parimal(3), Matthew Billups(3), Mirko Minervini(3), Andrew L. Zydney(3), Xuankuo Xu(3), Caryn L. Heldt(3), William Grimm(3)