Siddharth Parimal

GlaxoSmithKline (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index492citations13works0.02yr avg
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Research Topics

Protein purification and stability(9), Analytical Chemistry and Chromatography(6), Monoclonal and Polyclonal Antibodies Research(4), Enzyme Structure and Function(4), Protein Structure and Dynamics(2)

Publications13 total

Highland games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences
Biotechnology and Bioengineering·2020· 17 cited
Single Molecule Force Spectroscopy and Molecular Dynamics Simulations as a Combined Platform for Probing Protein Face-Specific Binding
Langmuir·2017· 28 cited
A molecular modeling based method to predict elution behavior and binding patches of proteins in multimodal chromatography
Journal of Chromatography A·2017· 25 cited
Effect of guanidine and arginine on protein–ligand interactions in multimodal cation‐exchange chromatography
Biotechnology Progress·2016· 16 cited
The effect of geometrical presentation of multimodal cation-exchange ligands on selective recognition of hydrophobic regions on protein surfaces
Journal of Chromatography A·2015· 67 cited
Interactions of Multimodal Ligands with Proteins: Insights into Selectivity Using Molecular Dynamics Simulations
Langmuir·2015· 30 cited
Investigation of protein selectivity in multimodal chromatography using <i>in silico</i> designed Fab fragment variants
Biotechnology and Bioengineering·2015· 48 cited
Investigation into the Molecular and Thermodynamic Basis of Protein Interactions in Multimodal Chromatography Using Functionalized Nanoparticles
Langmuir·2014· 43 cited
Application of a Spherical Harmonics Expansion Approach for Calculating Ligand Density Distributions around Proteins
The Journal of Physical Chemistry B·2014· 24 cited
Effects of Urea on Selectivity and Protein–Ligand Interactions in Multimodal Cation Exchange Chromatography
Langmuir·2012· 21 cited
Probing multimodal ligand binding regions on ubiquitin using nuclear magnetic resonance, chromatography, and molecular dynamics simulations
Journal of Chromatography A·2012· 37 cited
Mobile phase modifier effects in multimodal cation exchange chromatography
Biotechnology and Bioengineering·2011· 57 cited
Prediction of Equillibrium Sorption Isotherm: Comparison of Linear and Nonlinear Methods
Industrial & Engineering Chemistry Research·2010· 79 cited

Frequent Co-authors

Steven M. Cramer(11), Scott A. McCallum(4), Shekhar Garde(4), Melissa Holstein(3), James Woo(2), Kartik Srinivasan(2), Blanca Barquera(2), Suvrajit Banerjee(2), M.M. Prasad(1), Ujjwal Bhaskar(1), Matthew R. Brown(1), Ryan F. Heden(1), Hanne Sophie Karkov(1), Berit Olsen Krogh(1), Haleh Ahmadian(1), María M. López(1), Wai Keen Chung(1), Alexander S. Freed(1), Lars Sejergaard(1), Ronen Berkovich(1)