Kevin J. Robbins

AstraZeneca (Brazil) — Brazil

Medicine · Health Sciences

11h-index519citations17works8.82yr avg
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Research Topics

Alzheimer's disease research and treatments(6), Protein Structure and Dynamics(5), Chemical Synthesis and Analysis(3), Supramolecular Self-Assembly in Materials(3), Computational Drug Discovery Methods(2)

Publications17 total

Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome
Journal of Medicinal Chemistry·2025· 2 cited
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor
Journal of Medicinal Chemistry·2025· 15 cited
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
Journal of Medicinal Chemistry·2024· 8 citedOpen Access
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors
Journal of Medicinal Chemistry·2024· 10 citedOpen Access
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity
ACS Medicinal Chemistry Letters·2023· 12 citedOpen Access
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors
Bioorganic & Medicinal Chemistry Letters·2018· 13 citedOpen Access
NMR in drug design
Archives of Biochemistry and Biophysics·2017· 26 cited
Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products
Journal of the American Chemical Society·2017· 125 citedOpen Access
Development of New Benzenesulfonamides As Potent and Selective Na<sub>v</sub>1.7 Inhibitors for the Treatment of Pain
Journal of Medicinal Chemistry·2017· 36 citedOpen Access
Contextual Role of a Salt Bridge in the Phage P22 Coat Protein I-Domain
Journal of Biological Chemistry·2016· 9 citedOpen Access
K114 (<i>trans, trans</i>)‐bromo‐2,5‐bis(4‐hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils
Protein Science·2014· 7 citedOpen Access
Conformational Analysis of Thioflavin T Bound to the Surface of Amyloid Fibrils
Langmuir·2012· 55 cited
Kinetic Profile of Amyloid Formation in the Presence of an Aromatic Inhibitor by Nuclear Magnetic Resonance
ACS Medicinal Chemistry Letters·2012· 18 citedOpen Access
Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix
Biochemical and Biophysical Research Communications·2012· 62 cited
Helix-Dipole Effects in Peptide Self-Assembly to Amyloid
Biochemistry·2012· 5 cited
Detection of Strongly Bound Thioflavin T Species in Amyloid Fibrils by Ligand-Detected <sup>1</sup>H NMR
The Journal of Physical Chemistry Letters·2011· 31 cited
Mechanistic Studies of Peptide Self-Assembly: Transient α-Helices to Stable β-Sheets
Journal of the American Chemical Society·2010· 84 cited

Frequent Co-authors

Noel D. Lazo(7), Gai Liu(6), Gayathri Bommakanti(4), Kathryn A. Giblin(4), Adelphe M. Mfuh(4), Marianne Schimpl(4), Haoran Tang(4), Neil P. Grimster(4), Michelle L. Lamb(4), Samuel Sparks(3), Veli Selmani(3), Samantha Jane Hughes(3), Iswarya Karapa Reddy(3), Jeffrey A. Boerth(3), Alex J. Chinn(3), Christina Chan(3), Erin Code(3), Taylor R. Quinn(3), Jamie Ware(3), Gail L. Wrigley(3)