Matthew N. O’Brien

Gene Therapy Laboratory — France

Materials Science · Physical Sciences

23h-index2.5kcitations68works8.32yr avg
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Research Topics

Gold and Silver Nanoparticles Synthesis and Applications(32), Advanced biosensing and bioanalysis techniques(25), Quantum Dots Synthesis And Properties(13), DNA and Nucleic Acid Chemistry(10), RNA Interference and Gene Delivery(7)

Publications68 total

An Industry Perspective on the Use of Novel Excipients in Lipid Nanoparticles—Nonclinical Considerations
International Journal of Toxicology·2025· 1 citedOpen Access
Chemistry, manufacturing and controls strategies for using novel excipients in lipid nanoparticles
Nature Nanotechnology·2025· 30 cited
Development of a bio-relevant in vitro release testing method for subcutaneous and intramuscular oil depot formulations
Journal of Drug Delivery Science and Technology·2024· 2 citedOpen Access
Development of a Bio-Relevant in Vitro Release Testing Method for Subcutaneous and Intramuscular Oil Depot Formulations
SSRN Electronic Journal·2024Open Access
Self-Assembly Properties of an Amphiphilic Phosphate Ester Prodrug Designed for the Treatment of COVID-19
Journal of Pharmaceutical Sciences·2023· 1 citedOpen Access
Process Robustness in Lipid Nanoparticle Production: A Comparison of Microfluidic and Turbulent Jet Mixing
Molecular Pharmaceutics·2023· 56 citedOpen Access
Delivering on the promise of protein degraders
Nature Reviews Drug Discovery·2023· 83 cited
Challenges and opportunities in the development of complex generic long-acting injectable drug products
Journal of Controlled Release·2021· 118 cited
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19
2020· 158 citedOpen Access
Exploring the Zone of Anisotropy and Broken Symmetries in DNA-Mediated Nanoparticle Crystallization*
Spherical Nucleic Acids·2020
Anisotropic Nanoparticle Complementarity in DNA-Mediated Co-crystallization*
Spherical Nucleic Acids·2020
Programming Colloidal Crystal Habit with Anisotropic Nanoparticle Building Blocks and DNA Bonds*
Spherical Nucleic Acids·2020
Reconstitutable Nanoparticle Superlattices*
Spherical Nucleic Acids·2020Open Access
Building Superlattices from Individual Nanoparticles via Template-Confined DNA-Mediated Assembly*
Spherical Nucleic Acids·2020
Nucleic Acid-Modified Nanostructures as Programmable Atom Equivalents: Forging a New “Table of Elements”*
Spherical Nucleic Acids·2020· 2 cited
The Nature and Implications of Uniformity in the Hierarchical Organization of Nanomaterials*
Spherical Nucleic Acids·2020
Crystal Engineering with DNA*
Spherical Nucleic Acids·2020· 5 cited
Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals*
Spherical Nucleic Acids·2020
Deterministic Symmetry Breaking of Plasmonic Nanostructures Enabled by DNA-Programmable Assembly*
Spherical Nucleic Acids·2020Open Access
Exploring the Zone of Anisotropy and Broken Symmetries in DNA-Mediated Nanoparticle Crystallization*
Spherical Nucleic Acids·2020
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Frequent Co-authors

Chad A. Mirkin(36), Matthew R. Jones(15), Byeongdu Lee(12), George C. Schatz(9), Keith A. Brown(8), Christine R. Laramy(8), Vinayak P. Dravid(6), Jarad A. Mason(5), Kevin L. Kohlstedt(5), Martin Girard(5), Mónica Olvera de la Cruz(5), Jinsong Wu(5), Robert J. Macfarlane(4), Sarah Hurst Petrosko(4), Haixin Lin(4), Boya Radha(4), Serkan Bütün(3), Koray Aydın(3), Suman Luthra(3), Jaime A. Millan(3)