James R. Apgar

Pfizer (United States) — United States

Medicine · Health Sciences

14h-index805citations17works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(8), Protein Structure and Dynamics(5), Protein purification and stability(5), Glycosylation and Glycoproteins Research(4), RNA and protein synthesis mechanisms(3)

Publications17 total

Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation
Scientific Reports·2023· 31 citedOpen Access
Intein-modified enzymes, their production and industrial applications
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2023Open Access
Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody
mAbs·2021· 5 citedOpen Access
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors
mAbs·2021· 14 citedOpen Access
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
PLoS ONE·2020· 48 citedOpen Access
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease
Journal of Biological Chemistry·2020· 28 citedOpen Access
Establishing <i>in vitro in vivo</i> correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics
mAbs·2017· 97 citedOpen Access
Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody
mAbs·2016· 49 citedOpen Access
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer
Antibodies·2016· 93 citedOpen Access
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
Proceedings of the National Academy of Sciences·2015· 24 citedOpen Access
<scp>AB</scp> ‐Bind: Antibody binding mutational database for computational affinity predictions
Protein Science·2015· 180 citedOpen Access
Engineering a thermoregulated intein-modified xylanase into maize for consolidated lignocellulosic biomass processing
Nature Biotechnology·2012· 85 cited
A Predictive Model of Intein Insertion Site for Use in the Engineering of Molecular Switches
PLoS ONE·2012· 18 citedOpen Access
Cluster expansion models for flexible‐backbone protein energetics
Journal of Computational Chemistry·2009· 19 cited
Predicting helix orientation for coiled‐coil dimers
Proteins Structure Function and Bioinformatics·2008· 34 citedOpen Access
Modeling the flexibility of alpha helices in protein interfaces : structure based design and prediction of helix-mediated protein-protein interactions
DSpace@MIT (Massachusetts Institute of Technology)·2008Open Access
Modeling Backbone Flexibility to Achieve Sequence Diversity: The Design of Novel α-Helical Ligands for Bcl-xL
Journal of Molecular Biology·2007· 80 citedOpen Access

Frequent Co-authors

Amy King(5), Laura Lin(5), Eric M. Bennett(4), Amy E. Keating(4), Orla Cunningham(4), Aaron M. D’Antona(4), Lioudmila Tchistiakova(4), Jason Wade(3), Amy Tam(3), William J.J. Finlay(3), Laird Bloom(3), Matthew Lambert(3), Weijun Ma(3), Susan Benard(3), Nicole Piche‐Nicholas(2), Brian J. Fennell(2), Barry J. McDonnell(2), Adam Root(2), Caryl Meade(2), Alfredo Darmanin Sheehan(2)