Brian J. Fennell

Pfizer (United States) — United States

Medicine · Health Sciences

14h-index774citations20works6.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(12), Protein purification and stability(7), Malaria Research and Control(4), Glycosylation and Glycoproteins Research(4), T-cell and B-cell Immunology(3)

Publications20 total

How to think about designing smart antibodies in the age of genAI: integrating biology, technology, and experience
mAbs·2025· 6 citedOpen Access
Impacts of fast production of afucosylated antibodies and Fc mutants in ExpiCHO-S™ for enhancing FcγRIIIa binding and NK cell activation
Journal of Biotechnology·2022· 3 citedOpen Access
Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation
Antibody Therapeutics·2022· 4 citedOpen Access
Parallel Evolution of Antibody Affinity and Thermal Stability for Optimal Biotherapeutic Development
Methods in molecular biology·2018· 4 cited
Establishing <i>in vitro in vivo</i> correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics
mAbs·2017· 97 citedOpen Access
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
Proceedings of the National Academy of Sciences·2015· 24 citedOpen Access
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)
Journal of Biological Chemistry·2015· 24 citedOpen Access
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery
mAbs·2013· 33 citedOpen Access
Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites
Molecular and Biochemical Parasitology·2013· 25 cited
Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential
Journal of Molecular Biology·2013· 50 cited
An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition
Journal of Biological Chemistry·2012· 58 citedOpen Access
Molecular Scanning: Combining Random Mutagenesis, Ribosome Display, and Bioinformatic Analysis for Protein Engineering
Methods in molecular biology·2012· 1 cited
Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids
The Journal of Immunology·2011· 85 citedOpen Access
Dissection of the IgNAR V Domain: Molecular Scanning and Orthologue Database Mining Define Novel IgNAR Hallmarks and Affinity Maturation Mechanisms
Journal of Molecular Biology·2010· 41 cited
Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions
Journal of Molecular Biology·2009· 63 cited
A simple high-throughput purification method for hit identification in protein screening
Journal of Immunological Methods·2008· 20 cited
Isotype expression, post-translational modification and stage-dependent production of tubulins in erythrocytic Plasmodium falciparum
International Journal for Parasitology·2007· 45 cited
Cellular and molecular actions of dinitroaniline and phosphorothioamidate herbicides on Plasmodium falciparum: Tubulin as a specific antimalarial target
Molecular and Biochemical Parasitology·2005· 96 cited
Investigation of microtubule inhibitors as potential antimalarial agents
Trinity's Access to Research Output (TARA) (Trinity College Dublin)·2005Open Access
Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum
Journal of Antimicrobial Chemotherapy·2003· 95 cited

Frequent Co-authors

Orla Cunningham(13), William J.J. Finlay(9), Alfredo Darmanin-Sheehan(7), Janet Paulsen(6), Davinder Gill(6), Amy Tam(5), Laird Bloom(5), Matthew Lambert(5), Jason Wade(4), Laura Lin(4), Deirdre Ní Shúilleabháin(4), Bénédicte Autin(4), Emma Cummins(4), Amy King(3), Barry J. McDonnell(3), Angus Bell(3), Lioudmila Tchistiakova(3), Edward Franklin(3), Paul Sakorafas(2), James R. Apgar(2)