Alfredo Darmanin-Sheehan

Pfizer (United States) — United States

Medicine · Health Sciences

8h-index313citations11works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(8), Protein purification and stability(4), T-cell and B-cell Immunology(2), Advanced biosensing and bioanalysis techniques(2), Advanced Chemical Sensor Technologies(2)

Publications11 total

Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis
Journal of Immunology Research·2018· 12 citedOpen Access
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
Proceedings of the National Academy of Sciences·2015· 24 citedOpen Access
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery
mAbs·2013· 33 citedOpen Access
Molecular Scanning: Combining Random Mutagenesis, Ribosome Display, and Bioinformatic Analysis for Protein Engineering
Methods in molecular biology·2012· 1 cited
Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids
The Journal of Immunology·2011· 85 citedOpen Access
Dissection of the IgNAR V Domain: Molecular Scanning and Orthologue Database Mining Define Novel IgNAR Hallmarks and Affinity Maturation Mechanisms
Journal of Molecular Biology·2010· 41 cited
Applications of Sensors in Food and Environmental Analysis
2010· 1 cited
Applications of Sensors in Food and Environmental Analysis
2010· 1 cited
Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions
Journal of Molecular Biology·2009· 63 cited
A simple high-throughput purification method for hit identification in protein screening
Journal of Immunological Methods·2008· 20 cited
Advances in biosensors for detection of pathogens in food and water.
2005· 32 cited

Frequent Co-authors

Brian J. Fennell(7), Orla Cunningham(7), William J.J. Finlay(7), Emma Cummins(5), Janet Paulsen(4), Davinder Gill(4), Matthew Lambert(3), Deirdre Ní Shúilleabháin(3), Lioudmila Tchistiakova(3), Laird Bloom(3), Deborah Luxenberg(3), Matthew J. Whitters(3), Richard O’Kennedy(3), Paul Leonard(3), Stephen Hearty(3), Sharon Stapleton(3), Bénédicte Autin(2), Jason Wade(2), Simon E. Hufton(2), Barry J. McDonnell(2)