Janet Paulsen

Arrien Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index1.8kcitations35works0.02yr avg
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Research Topics

Genetics, Aging, and Longevity in Model Organisms(6), Monoclonal and Polyclonal Antibodies Research(6), Receptor Mechanisms and Signaling(6), Neuropeptides and Animal Physiology(5), Protein purification and stability(4)

Publications35 total

Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC)
Cancer Research·2024
Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets
Cancer Research·2023· 1 cited
Expanding the domain of applicability of structure-based drug design with IFD-MD
2020
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
Proceedings of the National Academy of Sciences·2015· 24 citedOpen Access
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery
mAbs·2013· 33 citedOpen Access
Activation of TrkB with TAM-163 Results in Opposite Effects on Body Weight in Rodents and Non-Human Primates
PLoS ONE·2013· 25 citedOpen Access
Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential
Journal of Molecular Biology·2013· 50 cited
An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition
Journal of Biological Chemistry·2012· 58 citedOpen Access
Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids
The Journal of Immunology·2011· 85 citedOpen Access
Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias)
Developmental & Comparative Immunology·2011· 43 cited
Primary sequence determination of a monoclonal antibody against α-synuclein using a novel mass spectrometry-based approach
International Journal of Mass Spectrometry·2011· 15 cited
Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-α Production in a Receptor for Advanced Glycation End Product-Dependent Manner
The Journal of Immunology·2010· 75 citedOpen Access
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production
American Journal of Physiology-Cell Physiology·2010· 21 cited
The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders?
Molecular and Cellular Neuroscience·2009· 94 cited
Direct interaction of receptor for advanced glycation end products with CPGa and complement component C3a augments interferon alpha in human PBMCs
Cytokine·2009
Oligomerization is required for the activity of recombinant soluble LOX‐1
FEBS Journal·2009· 28 citedOpen Access
Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions
Journal of Molecular Biology·2009· 63 cited
LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells
American Journal of Physiology-Cell Physiology·2009· 63 cited
CRP is a novel ligand for the oxidized LDL receptor LOX-1
American Journal of Physiology-Heart and Circulatory Physiology·2009· 79 cited
α-S-GalCer: Synthesis and evaluation for iNKT cell stimulation
Bioorganic & Medicinal Chemistry Letters·2008· 36 citedOpen Access
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Frequent Co-authors

Heather H. Shih(11), Davinder Gill(7), Susan Strome(6), Brian Bates(6), Brian J. Fennell(6), Orla Cunningham(6), Noël Taylor(5), Matthew Lambert(5), William J.J. Finlay(5), Jeremy Johnson(4), Leeying Wu(4), Alfredo Darmanin-Sheehan(4), Deirdre Ní Shúilleabháin(4), Bénédicte Autin(4), Lioudmila Tchistiakova(4), Ruth E. Gimeno(3), Emma Cummins(3), Laird Bloom(3), Christine Huard(3), Wenyan Zhong(3)