Matthew J. Whitters

Pfizer (United States) — United States

Immunology and Microbiology · Life Sciences

22h-index10.5kcitations26works0.02yr avg
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Research Topics

T-cell and B-cell Immunology(14), Immune Cell Function and Interaction(13), Immunotherapy and Immune Responses(7), Psoriasis: Treatment and Pathogenesis(5), Monoclonal and Polyclonal Antibodies Research(5)

Publications26 total

Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis
Journal of Immunology Research·2018· 12 citedOpen Access
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery
mAbs·2013· 33 citedOpen Access
Enhanced <scp>GITR</scp>/<scp>GITRL</scp> interactions augment <scp>IL</scp>‐27 expression and induce <scp>IL</scp>‐10‐producing Tr‐1 like cells
European Journal of Immunology·2012· 46 cited
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity (114.16)
The Journal of Immunology·2011· 68 cited
Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Science·2011· 1.0k cited
A simple high-throughput purification method for hit identification in protein screening
Journal of Immunological Methods·2008· 20 cited
The Human IL-17F/IL-17A Heterodimeric Cytokine Signals through the IL-17RA/IL-17RC Receptor Complex
The Journal of Immunology·2008· 311 citedOpen Access
An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment
The Journal of Immunology·2007· 370 citedOpen Access
The functional activity of human IL-17A, IL-17F and IL-17A/IL-17F cytokines is dependent on the receptors IL-17R and IL-17RC (94.31)
The Journal of Immunology·2007
Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
Arthritis & Rheumatism·2007· 271 cited
Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells
Journal of Biological Chemistry·2007· 309 citedOpen Access
Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells
The Journal of Immunology·2004· 498 cited
IL-21 Activates Both Innate and Adaptive Immunity to Generate Potent Antitumor Responses that Require Perforin but Are Independent of IFN-γ
The Journal of Immunology·2003· 163 cited
IL-21 Induces the Apoptosis of Resting and Activated Primary B Cells
The Journal of Immunology·2003· 197 citedOpen Access
Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2
The Journal of Experimental Medicine·2003· 183 citedOpen Access
Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response
The Journal of Experimental Medicine·2003· 252 citedOpen Access
IL-21 and IL-21 Receptor: A New Cytokine Pathway Modulates Innate and Adaptive Immunity
Immunologic Research·2003· 50 cited
Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
The Journal of Experimental Medicine·2002· 282 citedOpen Access
IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation
Immunity·2002· 474 citedOpen Access
CD4+CD25+ Immunoregulatory T Cells
Immunity·2002· 1.4k citedOpen Access
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Frequent Co-authors

Mary Collins(21), Deborah Young(9), Deborah Luxenberg(7), Jill F. Wright(6), Michael J. Grusby(6), Neil M. Wolfman(5), Jonathan Brooks(4), Beatriz M. Carreno(4), Debra D. Donaldson(4), Frann Bennett(4), Lori Fitz(4), Kyri Dunussi‐Joannopoulos(4), Leslie Lowe(3), Mayra Senices(3), Andrea L. Wurster(3), Kathleen Tomkinson(3), Alfredo Darmanin-Sheehan(3), Emma Cummins(3), John M. Wozney(2), Vicki Rosen(2)