M. L. Sá e Melo

Centro de Neurociências e Biologia Celular

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.3kcitations106works0.02yr avg
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Research Topics

Steroid Chemistry and Biochemistry(45), Estrogen and related hormone effects(25), Crystallization and Solubility Studies(17), X-ray Diffraction in Crystallography(17), Organic Chemistry Cycloaddition Reactions(14)

Publications106 total

Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?
Steroids·2015· 2 cited
Oxysterols and related sterols: Chemical, biochemical and biological aspects
Steroids·2015· 2 cited
Anticancer steroids: linking natural and semi-synthetic compounds
Natural Product Reports·2012· 270 cited
Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR
Journal of Medicinal Chemistry·2011· 52 cited
Androstane-3β,5α,6β,17β-tetrol trihydrate
Acta Crystallographica Section E Structure Reports Online·2011· 2 citedOpen Access
Oxiesteróis: O seu Papel na Saúde e na Doença
Boletim da Sociedade Portuguesa de Química·2011Open Access
3β,5α,6β-Trihydroxyandrostan-17-one
Acta Crystallographica Section E Structure Reports Online·2011· 7 citedOpen Access
Biocatalytic Transformations of Steroids: Focus on Hydrolase-Catalyzed Reactions
Current Organic Chemistry·2011· 4 cited
CCDC 834333: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Ligand-guided optimization of CXCR4 homology models for virtual screening using a multiple chemotype approach
Journal of Computer-Aided Molecular Design·2010· 23 cited
Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis
Journal of Medicinal Chemistry·2010· 68 cited
6-[(4-Fluorophenyl)(1<i>H</i>-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol and 6-[(4-methoxyphenyl)(1<i>H</i>-imidazol-1-yl)methyl]-1,3-benzodioxol-5-ol
Acta Crystallographica Section C Crystal Structure Communications·2010· 1 cited
6β-Methyl-<i>B</i>-norandrostenedione
Acta Crystallographica Section C Crystal Structure Communications·2010
Efficient trans-diaxial hydroxylation of Δ5-steroids
Tetrahedron·2010· 17 cited
CCDC 798597: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
CCDC 774902: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
CCDC 798596: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols
Journal of Medicinal Chemistry·2009· 29 cited
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors
European Journal of Medicinal Chemistry·2009· 42 citedOpen Access
Highly efficient epoxidation of unsaturated steroids using magnesium bis(monoperoxyphthalate) hexahydrate
Tetrahedron·2009· 32 cited
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Frequent Co-authors

A. S. Campos Neves(14), Maria Manuel Silva(12), J.A. Paixão(11), M. J. M. de Almeida(11), Jorge A. R. Salvador(10), João F. S. Carvalho(9), L. C. R. Andrade(9), María Moreno(8), E. J. Tavares da Silva(8), Marco A. C. Neves(6), Andre ́S. Campos Neves(5), Sérgio Simões(4), Teresa C.P. Dinis(4), Giorgio Colombo(4), Sergio Riva(4), Thies Thiemann(4), Alcino J. Leitão(3), João Nuno Moreira(3), Shuntarō Mataka(3), Saúl C. Costa(3)