Samantha Carreiro

Intarcia Therapeutics (United States) — United States

Medicine · Health Sciences

11h-index1.0kcitations28works0.92yr avg
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Research Topics

Glaucoma and retinal disorders(6), Nitric Oxide and Endothelin Effects(4), Inflammatory mediators and NSAID effects(4), Melanoma and MAPK Pathways(4), Retinal Diseases and Treatments(3)

Publications28 total

Structurally Enabling ADMET Anti-Targets via Induced Fit Docking and Free Energy Perturbation
2026Open Access
Structurally Enabling ADMET Anti-Targets via Induced Fit Docking and Free Energy Perturbation
2026Open Access
Applying Mechanistic PKPD Models to Differentiate Inhibitors of Werner Syndrome Helicase Based on Predicted in vivo Target Engagement
2026Open Access
Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors
Journal of Medicinal Chemistry·2025
Highly selective HPK1 inhibitor NDI-101150 mediates immune cell activation and robust antitumor responses, distinct from immune checkpoint blockade
Journal for ImmunoTherapy of Cancer·2025· 3 citedOpen Access
Abstract 2894: NTX-452: a non-covalent, potent, selective and highly efficacious WRN inhibitor with best-in-class potential for the treatment of MSI-H tumors
Cancer Research·2025· 3 cited
356 (PB344): Preclinical characterization of NTX-452, a potent, selective and highly efficacious WRN inhibitor for the treatment of MSI-H tumors
European Journal of Cancer·2024
1340 NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1) inhibitor that promotes a robust and broad anti-tumor immune response
Regular and Young Investigator Award Abstracts·2023· 2 citedOpen Access
Discovery and characterization of novel inhibitors of CTP synthase 1 (CTPS1) for the treatment of autoimmune and inflammatory disease
The Journal of Immunology·2023· 2 citedOpen Access
Abstract 1649: Mechanistic understanding of HPK1 inhibition on enhanced human T cell activation and tumor immunity in a syngeneic model
Cancer Research·2021· 1 cited
685 A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model
Regular and Young Investigator Award Abstracts·2020· 1 citedOpen Access
A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model
European Journal of Cancer·2020· 1 cited
Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches
Bioelectronic Medicine·2019· 7 citedOpen Access
The Class I HDAC inhibitor RGFP963 enhances consolidation of cued fear extinction
Learning & Memory·2015· 49 citedOpen Access
HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner
Proceedings of the National Academy of Sciences·2013· 408 citedOpen Access
Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating Prostaglandin F2α agonist, in preclinical models
Experimental Eye Research·2011· 111 cited
Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucoma
Experimental Eye Research·2011· 64 cited
A dual acting compound with latanoprost amide and nitric oxide releasing properties, shows ocular hypotensive effects in rabbits and dogs
Experimental Eye Research·2011· 32 cited
Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice
Amyotrophic Lateral Sclerosis·2010· 17 cited
A Novel Nitric Oxide Releasing Prostaglandin Analog, NCX 125, Reduces Intraocular Pressure in Rabbit, Dog, and Primate Models of Glaucoma
Journal of Ocular Pharmacology and Therapeutics·2010· 69 cited
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Frequent Co-authors

Ganesh Prasanna(11), Peter J. Tummino(10), Achim H.‐P. Krauss(9), Neelu Kaila(7), David C. Gale(6), Hovhannes J. Gukasyan(6), Justin A. Caravella(6), David Ciccone(6), Cathie Xiang(5), Soisurin Sartnurak(5), Angela V. Toms(5), Joshua McElwee(5), Francesco Impagnatiello(4), Valerio Chiroli(4), Wesley K. M. Chong(4), Scott Anderson(4), Michael R. Niesman(4), Jennifer Lafontaine(4), Scott Boiko(4), Christine Loh(4)