Amy E. Baxter

Children's Hospital of Philadelphia — United States

Immunology and Microbiology · Life Sciences

43h-index10.8kcitations86works12.22yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Immune Cell Function and Interaction(34), COVID-19 Clinical Research Studies(22), T-cell and B-cell Immunology(21), SARS-CoV-2 and COVID-19 Research(19), CAR-T cell therapy research(18)

Publications86 total

Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and roles in disease
Nature Immunology·2025· 3 cited
Multimodal analysis defines <i>GNG4</i> as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
2025· 1 citedOpen Access
Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 <sup>+</sup> T cells underlies distinct functional potential
2025· 1 citedOpen Access
Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion
The Journal of Immunology·2025
Deciphering the role of histone modifications in memory and exhausted CD8 T cells
Scientific Reports·2025· 4 citedOpen Access
Deciphering the role of histone modifications in memory and exhausted CD8 T cells
2025Open Access
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
Science Immunology·2025· 24 cited
TET2 regulates early and late transitions in exhausted CD8 <sup>+</sup> T cell differentiation and limits CAR T cell function
Science Advances·2024· 18 citedOpen Access
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
Cell·2024· 77 citedOpen Access
TET2 regulates early and late transitions in exhausted CD8 <sup>+</sup> T-cell differentiation and limits CAR T-cell function
2024Open Access
A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma
2024· 6 citedOpen Access
1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX
Regular and Young Investigator Award Abstracts·2023Open Access
222-J Longitudinal spatial profiling of pediatric high-grade glioma reveals a heterogeneous and dynamic immune microenvironment with therapeutic implications
2023Open Access
Serotonin reduction in post-acute sequelae of viral infection
Cell·2023· 326 citedOpen Access
Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection
Nature Immunology·2023· 99 citedOpen Access
In vitro modeling of CD8 <sup>+</sup> T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40
Science Immunology·2023· 81 citedOpen Access
The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
Cell Reports·2023· 11 citedOpen Access
The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
Immunity·2023· 71 cited
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Nature Biotechnology·2023· 101 citedOpen Access
<i>In Vitro</i> Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40
2023· 4 citedOpen Access
page 1 of 5Next →

Frequent Co-authors

E. John Wherry(38), Josephine R. Giles(27), Divij Mathew(26), Scott E. Hensley(25), Allison R. Greenplate(24), Sigrid Gouma(24), Madison E. Weirick(22), Derek A. Oldridge(21), Oliva Kuthuru(20), Ajinkya Pattekar(20), Laura A. Vella(19), Sokratis A. Apostolidis(18), Jeanette Dougherty(16), Kurt D’Andrea(15), Nuala J. Meyer(15), Jennifer E. Wu(14), Leticia Kuri-Cervantes(14), Michael R. Betts(14), Sharon Adamski(13), Paul Bates(13)