Dennis J. Templeton

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index8.2kcitations81works0.02yr avg
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Research Topics

Melanoma and MAPK Pathways(16), Protein Kinase Regulation and GTPase Signaling(10), Cancer-related Molecular Pathways(10), Genomics, phytochemicals, and oxidative stress(10), Polyomavirus and related diseases(8)

Publications81 total

Effects of Detarium Microcarpum And Securidaca Longepedunculata Extracts On Human Breast Adenocarcinoma MDA-MB231 Cells Proliferation
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH 2 -terminal Kinase (JNK/SAPK)
UNC Libraries·2021Open Access
Macrophage Migration Inhibitory Factor protects cancer cells from immunogenic cell death and impairs anti-tumor immune responses
PLoS ONE·2018· 104 citedOpen Access
Balogh et al. PLOS One Underlying Data Files
Arabixiv (OSF Preprints)·2018
Detarium microcarpum Stem Bark Extracts Induce Apoptosis in Human Breast Adenocarcinoma MDA MB 231 Cells via cJNK Activation and Mitochondrial Cytochrome C Release
Journal of Pharmaceutical and Biomedical Sciences·2016· 2 cited
Abstract 2812: Macrophage Migration Inhibitory Factor (MIF) regulates monocytic MDSC abundance to contribute to tumor growth and metastasis.
Cancer Research·2013
Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1
PLoS ONE·2012· 18 citedOpen Access
Macrophage Migration Inhibitory Factor Promotes Tumor Growth and Metastasis by Inducing Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
The Journal of Immunology·2012· 210 citedOpen Access
A new molecular mechanism for blockade of prostaglandin E2 expression by sulforaphane
The FASEB Journal·2012
Abstract 4369: The macrophage migration inhibitory factor (MIF) contributes to tumor growth and metastasis though interaction with the host immune response
Cancer Research·2012
Proteomic Profile of Reversible Protein Oxidation Using PROP, Purification of Reversibly Oxidized Proteins
PLoS ONE·2012· 19 citedOpen Access
PICquant: A Quantitative Platform To Measure Differential Peptide Abundance Using Dual-Isotopic Labeling with <sup>12</sup>C<sub>6</sub>- and <sup>13</sup>C<sub>6</sub>-Phenyl Isocyanate
Analytical Chemistry·2010· 4 citedOpen Access
Purification of Reversibly Oxidized Proteins (PROP) Reveals a Redox Switch Controlling p38 MAP Kinase Activity
PLoS ONE·2010· 44 citedOpen Access
JNK-mediated Phosphorylation of Cdc25C Regulates Cell Cycle Entry and G2/M DNA Damage Checkpoint
Journal of Biological Chemistry·2010· 80 citedOpen Access
MAZIE: A mass and charge inference engine to enhance database searching of tandem mass spectra
Journal of the American Society for Mass Spectrometry·2009· 6 cited
Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)
Biochemical Journal·2009· 71 citedOpen Access
Urokinase directly activates matrix metalloproteinases-9: A potential role in glioblastoma invasion
Biochemical and Biophysical Research Communications·2008· 74 citedOpen Access
The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase
BMC Cancer·2007· 39 citedOpen Access
PICquant‐ an automated platform for biomarker discovery in complex patient materials
The FASEB Journal·2007
Regulation of Signal Transduction Through Protein Cysteine Oxidation
Antioxidants and Redox Signaling·2006· 162 cited
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Frequent Co-authors

Janet V. Cross(16), Yongyi Qian(5), Joseph C. Deak(4), James R. Woodgett(4), Minhong Yan(3), Louis A. Parrott(3), Walter Eckhart(3), Joshua M. Rady(3), Roger J. Davis(2), Tse‐Hua Tan(2), John Kyriakis(2), Leonard I. Zon(2), Lynn E. Horton(2), Margaret Reed Lewis(2), Brent W. Zanke(2), Elizabeth A. Rich(2), Charles E. Lyons(2), Frank W. Foss(2), Timothy L. Macdonald(2), Hsing‐Jien Kung(2)