Alessandra Rufini

University of Rome Tor Vergata — Italy

Neuroscience · Life Sciences

16h-index1.4kcitations36works1.02yr avg
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Research Topics

Genetic Neurodegenerative Diseases(18), Mitochondrial Function and Pathology(16), Cell death mechanisms and regulation(4), Glycosylation and Glycoproteins Research(4), Ubiquitin and proteasome pathways(4)

Publications36 total

A Pilot Phase 2 Randomized Trial to Evaluate the Safety and Potential Efficacy of Etravirine in Friedreich Ataxia Patients
Children·2024· 2 citedOpen Access
An RNA-seq study in Friedreich ataxia patients identified hsa-miR-148a-3p as a putative prognostic biomarker of the disease
Human Genomics·2024Open Access
A Pilot Phase 2 Randomized Trial to Evaluate the Safety and Potential Efficacy of Etravirine in Friedreich Ataxia Patients
Preprints.org·2024· 1 citedOpen Access
Interferon Gamma Enhances Cytoprotective Pathways via Nrf2 and MnSOD Induction in Friedreich’s Ataxia Cells
International Journal of Molecular Sciences·2023· 4 citedOpen Access
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo
Biology Direct·2023· 9 citedOpen Access
Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma
Frontiers in Medicine·2023· 18 citedOpen Access
Drug Repositioning in Friedreich Ataxia
Frontiers in Neuroscience·2022· 13 citedOpen Access
Hsa-miR223-3p circulating level is upregulated in Friedreich’s ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1
Human Molecular Genetics·2022· 5 citedOpen Access
Sensitivity of Neuroimaging Indicators in Monitoring the Effects of Interferon Gamma Treatment in Friedreich’s Ataxia
Frontiers in Neuroscience·2020· 9 citedOpen Access
Safety and Efficacy Of Interferon γ in Friedreich's Ataxia
Movement Disorders·2020· 12 citedOpen Access
Frataxin deficiency in Friedreich’s ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte death and survival
Human Molecular Genetics·2020· 11 citedOpen Access
Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia
Movement Disorders·2019· 33 cited
Biophysical characterisation of the recombinant human frataxin precursor
FEBS Open Bio·2018· 10 citedOpen Access
Experimental assessment of the water content influence on thermo-acoustic performance of building insulation materials
Construction and Building Materials·2017· 43 cited
E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia
Cell Reports·2017· 42 citedOpen Access
Src inhibitors modulate frataxin protein levels
Human Molecular Genetics·2015· 16 citedOpen Access
Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells
Neurobiology of Disease·2014· 33 citedOpen Access
7th Tuscany Retreat on Cancer Research: Genetic profiling, resistance mechanism and novel treatment concepts in cancer
Cell Death and Differentiation·2011· 1 citedOpen Access
Frataxin participates to the hypoxia-induced response in tumors
Cell Death and Disease·2011· 56 citedOpen Access
Preventing the ubiquitin–proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia
Human Molecular Genetics·2011· 54 citedOpen Access
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Frequent Co-authors

Roberto Testi(26), Ivano Condò(22), Florence Malisan(18), Dario Serio(8), Silvia Fortuni(8), Barbara Tomassini(7), Maria Rita Rippo(5), Paola Costantini(5), Natascia Ventura(5), Monica Benini(5), Nicola Toschi(5), Eleonora Candi(4), Gerry Melino(4), Santos A. Susín(4), Guido Kroemer(4), Gaetano Arcuri(4), Riccardo Luffarelli(4), Luca Panarello(4), Andrea Martinuzzi(4), Andrea Quatrana(4)