Maria Angela Sortino

University of Catania — Italy

Medicine · Health Sciences

46h-index6.4kcitations179works0.82yr avg
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Research Topics

Alzheimer's disease research and treatments(38), Neuroscience and Neuropharmacology Research(36), Neuroinflammation and Neurodegeneration Mechanisms(28), Growth Hormone and Insulin-like Growth Factors(17), Estrogen and related hormone effects(15)

Publications179 total

Calcineurin inhibition mitigates activation of enteric glia in vitro and affects their crosstalk with macrophages
Neurochemistry International·2026Open Access
(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity
ACS Chemical Neuroscience·2025Open Access
Hypoxia reverses the early anti-inflammatory microglial response to the β-amyloid peptide: mitochondrial involvement and beneficial roles of melatonin and naringenin
Journal of Translational Medicine·2025· 2 citedOpen Access
Group II metabotropic glutamate receptors modulate blood brain barrier function: direct and indirect effect through astrocytes and microglia
European Journal of Pharmacology·2025Open Access
Cholesterol metabolites modulate ionotropic P2X4 and P2X7 receptor current in microglia cells
Neuropharmacology·2025· 1 citedOpen Access
Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson’s disease
npj Parkinson s Disease·2025· 2 citedOpen Access
Increased Heat Pain Tolerance but Hyperalgesia to Tonic Inflammatory Pain in the CRND8 Mouse Model of Alzheimer’s Disease
Journal of Alzheimer s Disease·2023· 2 citedOpen Access
Microglia and the Blood–Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions
International Journal of Molecular Sciences·2023· 62 citedOpen Access
Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells
Biomolecules·2023· 9 citedOpen Access
Purinergic ionotropic P2X7 and metabotropic glutamate mGlu5 receptors crosstalk influences pro-inflammatory conditions in microglia
European Journal of Pharmacology·2022· 14 cited
Microglia Contributes to BAF-312 Effects on Blood–Brain Barrier Stability
Biomolecules·2022· 13 citedOpen Access
Inverse correlation between the expression of AMPK/SIRT1 and NAMPT in psoriatic skin: A pilot study
Advances in Medical Sciences·2022· 9 cited
Microglial polarization differentially affects neuronal vulnerability to the β-amyloid protein: Modulation by melatonin
Biochemical Pharmacology·2022· 8 cited
Sphingosine-1-phosphate and Sphingosine-1-phosphate receptors in the cardiovascular system: pharmacology and clinical implications
Advances in pharmacology·2022· 4 cited
Decreased Astrocytic CCL2 Accounts for BAF-312 Effect on PBMCs Transendothelial Migration Through a Blood Brain Barrier in Vitro Model
Journal of Neuroimmune Pharmacology·2021· 13 citedOpen Access
SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin
Biomedicines·2021· 33 citedOpen Access
Protective effect of the sphingosine-1 phosphate receptor agonist siponimod on disrupted blood brain barrier function
Biochemical Pharmacology·2021· 27 cited
Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid
Frontiers in Molecular Neuroscience·2020· 18 citedOpen Access
Correction: Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer’s disease mouse model
Cell Death and Disease·2020· 50 citedOpen Access
The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs
Pharmaceuticals·2020· 418 citedOpen Access
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Frequent Co-authors

Ferdinando Nicoletti(22), Filippo Caraci(16), Simona Federica Spampinato(14), Agata Copani(14), Pier Luigi Canonico(13), Sara Merlo(12), Carlo Vancheri(10), Agata Copani(8), Filippo Drago(8), Giuseppe Battaglia(6), Valeria Bruno(5), Nunzio Crimi(5), Fabrizio Condorelli(4), Marco Calafiore(4), Giuseppe Caruso(4), Mariangela Chisari(4), Elisa Gili(3), Marco Failla(3), Tiziana Genovese(3), Salvatore Cuzzocrea(3)