Simona Federica Spampinato

University of Turin — Italy

Neuroscience · Life Sciences

25h-index2.4kcitations59works0.02yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(20), Alzheimer's disease research and treatments(17), Neuroscience and Neuropharmacology Research(9), Barrier Structure and Function Studies(9), Neuropeptides and Animal Physiology(7)

Publications59 total

Balancing the Cellular Inflammatory-Homeostatic Axis Through Natural Ingredient Supplementation
Nutrients·2025Open Access
Group II metabotropic glutamate receptors modulate blood brain barrier function: direct and indirect effect through astrocytes and microglia
European Journal of Pharmacology·2025Open Access
Editorial: The pharmacological modulation of angiogenesis
Frontiers in Pharmacology·2024Open Access
Microglia and the Blood–Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions
International Journal of Molecular Sciences·2023· 62 citedOpen Access
Microglia Contributes to BAF-312 Effects on Blood–Brain Barrier Stability
Biomolecules·2022· 13 citedOpen Access
Microglial polarization differentially affects neuronal vulnerability to the β-amyloid protein: Modulation by melatonin
Biochemical Pharmacology·2022· 8 cited
CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms
Biomolecules·2022· 8 citedOpen Access
An In Vitro Model of the Blood–Brain Barrier to Study Alzheimer’s Disease: The Role of β-Amyloid and Its Influence on PBMC Infiltration
Methods in molecular biology·2022· 4 cited
Sphingosine-1-phosphate and Sphingosine-1-phosphate receptors in the cardiovascular system: pharmacology and clinical implications
Advances in pharmacology·2022· 4 cited
Molecular Aspects of Cellular Dysfunction in Alzheimer’s Disease: The Need for a Holistic View of the Early Pathogenesis
Biomolecules·2021· 6 citedOpen Access
Decreased Astrocytic CCL2 Accounts for BAF-312 Effect on PBMCs Transendothelial Migration Through a Blood Brain Barrier in Vitro Model
Journal of Neuroimmune Pharmacology·2021· 13 citedOpen Access
SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin
Biomedicines·2021· 33 citedOpen Access
Protective effect of the sphingosine-1 phosphate receptor agonist siponimod on disrupted blood brain barrier function
Biochemical Pharmacology·2021· 27 cited
Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid
Frontiers in Molecular Neuroscience·2020· 18 citedOpen Access
The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs
Pharmaceuticals·2020· 418 citedOpen Access
SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence
Biomolecules·2020· 35 citedOpen Access
The Ambiguous Role of Microglia in Aβ Toxicity: Chances for Therapeutic Intervention
Current Neuropharmacology·2020· 32 citedOpen Access
β-amyloid and Oxidative Stress: Perspectives in Drug Development
Current Pharmaceutical Design·2019· 41 cited
Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood–Brain Barrier Integrity
Frontiers in Pharmacology·2019· 80 citedOpen Access
Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model
Frontiers in Cellular Neuroscience·2019· 22 citedOpen Access
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Frequent Co-authors

Maria Angela Sortino(34), Sara Merlo(27), Ferdinando Nicoletti(11), Yasuteru Sano(10), Takashi Kanda(10), Filippo Caraci(9), Yukio Takeshita(6), Birgit Obermeier(6), Agata Copani(6), Giuseppe Costantino(6), Grazia Ilaria Caruso(5), Richard M. Ransohoff(5), Filippo Drago(4), Giuseppe Battaglia(4), Valeria Bruno(4), Giuseppe Ronsisvalle(4), Orazio Prezzavento(4), Agostino Marrazzo(4), Giuseppe Caruso(3), Pier Luigi Canonico(3)